@article{006fe58a5da147aca130d66bcf0afc88,
title = "A multicomponent reaction of 2-aminoimidazoles: microwave-assisted synthesis of novel 5-aza-7-deaza-adenines",
abstract = "An efficient and highly selective multicomponent synthesis of 4-aminoimidazo[1,2-a][1,3,5]triazines, which are 5-aza-7-deaza-isosteres of adenine, was developed. The reaction of 2-aminoimidazoles, triethyl orthoformate and cyanamide under microwave irradiation proceeded regioselectively to provide a library of novel 5-aza-7-deaza-adenines in good yields and purity. The developed method was demonstrated to be scalable and highly reproducible in three different monomode microwave reactors. A rearrangement was proposed to explain the high selectivity of the reaction.",
author = "Lim, {Felicia Phei Lin} and Low, {Szy Teng} and Ho, {Elvina Lee King} and Halcovitch, {Nathan R.} and Tiekink, {Edward R.T.} and Dolzhenko, {Anton V.}",
note = "Funding Information: This work is supported by the Ministry of Higher Education, Malaysia under Fundamental Research Grant Scheme (FRGS). We would like to thank Nexus Analytics Sdn. Bhd. and Anton Paar Malaysia Sdn. Bhd. for their technical support. Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2017",
doi = "10.1039/c7ra11305f",
language = "English",
volume = "7",
pages = "51062--51068",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "The Royal Society of Chemistry",
number = "81",
}