A multi-step continuous flow process for the N-demethylation of alkaloids

Yuji Nakano, G Paul Savage, Simon Saubern, Peter John Scammells, Anastasios Polyzos

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)


Dextromethorphan was N-demethylated using the non-classical Polonovski reaction under continuous flow conditions, in two steps: initial N-oxidation with m-chloroperbenzoic acid followed by iron-catalysed N-demethylation of the resulting N-oxide.
Original languageEnglish
Pages (from-to)178 - 182
Number of pages5
JournalAustralian Journal of Chemistry
Issue number2
Publication statusPublished - 2013

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