A multi-step continuous flow process for the N-demethylation of alkaloids

Yuji Nakano; G Paul Savage; Simon Saubern; Peter John Scammells; Anastasios Polyzos

doi:10.1071/CH12463

A multi-step continuous flow process for the N-demethylation of alkaloids

Yuji Nakano, G Paul Savage, Simon Saubern, Peter John Scammells, Anastasios Polyzos

Medicinal Chemistry

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Dextromethorphan was N-demethylated using the non-classical Polonovski reaction under continuous flow conditions, in two steps: initial N-oxidation with m-chloroperbenzoic acid followed by iron-catalysed N-demethylation of the resulting N-oxide.

Original language	English
Pages (from-to)	178 - 182
Number of pages	5
Journal	Australian Journal of Chemistry
Volume	66
Issue number	2
DOIs	https://doi.org/10.1071/CH12463
Publication status	Published - 2013

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10.1071/CH12463

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title = "A multi-step continuous flow process for the N-demethylation of alkaloids",

abstract = "Dextromethorphan was N-demethylated using the non-classical Polonovski reaction under continuous flow conditions, in two steps: initial N-oxidation with m-chloroperbenzoic acid followed by iron-catalysed N-demethylation of the resulting N-oxide.",

author = "Yuji Nakano and Savage, {G Paul} and Simon Saubern and Scammells, {Peter John} and Anastasios Polyzos",

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T1 - A multi-step continuous flow process for the N-demethylation of alkaloids

AU - Nakano, Yuji

AU - Savage, G Paul

AU - Saubern, Simon

AU - Scammells, Peter John

AU - Polyzos, Anastasios

PY - 2013

Y1 - 2013

N2 - Dextromethorphan was N-demethylated using the non-classical Polonovski reaction under continuous flow conditions, in two steps: initial N-oxidation with m-chloroperbenzoic acid followed by iron-catalysed N-demethylation of the resulting N-oxide.

AB - Dextromethorphan was N-demethylated using the non-classical Polonovski reaction under continuous flow conditions, in two steps: initial N-oxidation with m-chloroperbenzoic acid followed by iron-catalysed N-demethylation of the resulting N-oxide.

UR - http://www.publish.csiro.au.ezproxy.lib.monash.edu.au/?act=view_file&file_id=CH12463.pdf

U2 - 10.1071/CH12463

DO - 10.1071/CH12463

M3 - Article

VL - 66

SP - 178

EP - 182

JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

SN - 0004-9425

IS - 2

ER -

A multi-step continuous flow process for the N-demethylation of alkaloids

Abstract

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