A modern ionotropic glutamate receptor with a K+ selectivity signature sequence

H. Janovjak, G. Sandoz, E. Y. Isacoff

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and gates non-selective cation channels. The origins of glutamate receptors are not well understood as they differ structurally and functionally from simple bacterial ligand-gated ion channels. Here we report the discovery of an ionotropic glutamate receptor that combines the typical eukaryotic domain architecture with the 'TXVGYG' signature sequence of the selectivity filter found in K+ channels. This receptor exhibits functional properties intermediate between bacterial and eukaryotic glutamate-gated ion channels, suggesting a link in the evolution of ionotropic glutamate receptors.

Original languageEnglish
Article number232
JournalNature Communications
Volume2
Issue number1
DOIs
Publication statusPublished - 2011
Externally publishedYes

Cite this