A model for understanding gene regulation during spermatogenesis: The mouse testis pdha-2 promoter

Rocco C. Iannello, Julia Young, Sony Sumarsono, Martin Tymms, Ismail Kola

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Spermatogenesis is a complex process requiring the coordinate expression of a number of testis-specific genes. How these genes are regulated during spermatogenesis is poorly understood. However, the elucidation of these mechanisms has significant implications for both medicine and the primary livestock industry. The delineation of this process is of particular interest and, in this study, Pdha-2, a gene which codes for the murine testis-specific isoform of the Elof subunit of the pyruvate dehydrogenase complex, has been used as a model. This review focuses on current knowledge about its expression and regulation during spermatogenesis.

Original languageEnglish
Pages (from-to)705-712
Number of pages8
JournalReproduction, Fertility and Development
Issue number4
Publication statusPublished - 1 Jan 1995
Externally publishedYes


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  • Transgenic mice

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