A missing piece

The spiny mouse and the puzzle of menstruating species

Nadia Bellofiore, Fiona Cousins, Peter Temple-Smith, Hayley Dickinson, Jemma Evans

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

We recently discovered the first known menstruating rodent. With the exception of four bats and the elephant shrew, the common spiny mouse (Acomys cahirinus) is the only species outside the primate order to exhibit menses. There are few widely accepted theories on why menstruation developed as the preferred reproductive strategy of these select mammals, all of which reference the evolution of spontaneous decidualisation prior to menstrual shedding. Though menstruating species share several reproductive traits, there has been no identifiable feature unique to menstruating species. Such a feature might suggest why spontaneous decidualisation, and thus menstruation, evolved in these species. We propose that a ≥3-fold increase in progesterone during the luteal phase of the reproductive cycle is a unique characteristic linking menstruating species. We discuss spontaneous decidualisation as a consequence of high progesterone, and the potential role of prolactin in screening for defective embryos in these species to aid in minimising implantation of abnormal embryos. We further explore the possible impact of nutrition in selecting species to undergo spontaneous decidualisation and subsequent menstruation. We summarise the current knowledge of menstruation, discuss current pre-clinical models of menstruation and how the spiny mouse may benefit advancing our understanding of this rare biological phenomenon.

Original languageEnglish
Pages (from-to)R25-R41
Number of pages17
JournalJournal of Molecular Endocrinology
Volume61
Issue number1
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • Decidualisation
  • Evolution
  • Hormones
  • Menstruation

Cite this

@article{13e59a57eaec4edaa5bcf9a987cee32e,
title = "A missing piece: The spiny mouse and the puzzle of menstruating species",
abstract = "We recently discovered the first known menstruating rodent. With the exception of four bats and the elephant shrew, the common spiny mouse (Acomys cahirinus) is the only species outside the primate order to exhibit menses. There are few widely accepted theories on why menstruation developed as the preferred reproductive strategy of these select mammals, all of which reference the evolution of spontaneous decidualisation prior to menstrual shedding. Though menstruating species share several reproductive traits, there has been no identifiable feature unique to menstruating species. Such a feature might suggest why spontaneous decidualisation, and thus menstruation, evolved in these species. We propose that a ≥3-fold increase in progesterone during the luteal phase of the reproductive cycle is a unique characteristic linking menstruating species. We discuss spontaneous decidualisation as a consequence of high progesterone, and the potential role of prolactin in screening for defective embryos in these species to aid in minimising implantation of abnormal embryos. We further explore the possible impact of nutrition in selecting species to undergo spontaneous decidualisation and subsequent menstruation. We summarise the current knowledge of menstruation, discuss current pre-clinical models of menstruation and how the spiny mouse may benefit advancing our understanding of this rare biological phenomenon.",
keywords = "Decidualisation, Evolution, Hormones, Menstruation",
author = "Nadia Bellofiore and Fiona Cousins and Peter Temple-Smith and Hayley Dickinson and Jemma Evans",
year = "2018",
month = "7",
day = "1",
doi = "10.1530/JME-17-0278",
language = "English",
volume = "61",
pages = "R25--R41",
journal = "Journal of Molecular Endocrinology",
issn = "0952-5041",
publisher = "Bioscientifica",
number = "1",

}

A missing piece : The spiny mouse and the puzzle of menstruating species. / Bellofiore, Nadia; Cousins, Fiona; Temple-Smith, Peter; Dickinson, Hayley; Evans, Jemma.

In: Journal of Molecular Endocrinology, Vol. 61, No. 1, 01.07.2018, p. R25-R41.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - A missing piece

T2 - The spiny mouse and the puzzle of menstruating species

AU - Bellofiore, Nadia

AU - Cousins, Fiona

AU - Temple-Smith, Peter

AU - Dickinson, Hayley

AU - Evans, Jemma

PY - 2018/7/1

Y1 - 2018/7/1

N2 - We recently discovered the first known menstruating rodent. With the exception of four bats and the elephant shrew, the common spiny mouse (Acomys cahirinus) is the only species outside the primate order to exhibit menses. There are few widely accepted theories on why menstruation developed as the preferred reproductive strategy of these select mammals, all of which reference the evolution of spontaneous decidualisation prior to menstrual shedding. Though menstruating species share several reproductive traits, there has been no identifiable feature unique to menstruating species. Such a feature might suggest why spontaneous decidualisation, and thus menstruation, evolved in these species. We propose that a ≥3-fold increase in progesterone during the luteal phase of the reproductive cycle is a unique characteristic linking menstruating species. We discuss spontaneous decidualisation as a consequence of high progesterone, and the potential role of prolactin in screening for defective embryos in these species to aid in minimising implantation of abnormal embryos. We further explore the possible impact of nutrition in selecting species to undergo spontaneous decidualisation and subsequent menstruation. We summarise the current knowledge of menstruation, discuss current pre-clinical models of menstruation and how the spiny mouse may benefit advancing our understanding of this rare biological phenomenon.

AB - We recently discovered the first known menstruating rodent. With the exception of four bats and the elephant shrew, the common spiny mouse (Acomys cahirinus) is the only species outside the primate order to exhibit menses. There are few widely accepted theories on why menstruation developed as the preferred reproductive strategy of these select mammals, all of which reference the evolution of spontaneous decidualisation prior to menstrual shedding. Though menstruating species share several reproductive traits, there has been no identifiable feature unique to menstruating species. Such a feature might suggest why spontaneous decidualisation, and thus menstruation, evolved in these species. We propose that a ≥3-fold increase in progesterone during the luteal phase of the reproductive cycle is a unique characteristic linking menstruating species. We discuss spontaneous decidualisation as a consequence of high progesterone, and the potential role of prolactin in screening for defective embryos in these species to aid in minimising implantation of abnormal embryos. We further explore the possible impact of nutrition in selecting species to undergo spontaneous decidualisation and subsequent menstruation. We summarise the current knowledge of menstruation, discuss current pre-clinical models of menstruation and how the spiny mouse may benefit advancing our understanding of this rare biological phenomenon.

KW - Decidualisation

KW - Evolution

KW - Hormones

KW - Menstruation

UR - http://www.scopus.com/inward/record.url?scp=85051061968&partnerID=8YFLogxK

U2 - 10.1530/JME-17-0278

DO - 10.1530/JME-17-0278

M3 - Review Article

VL - 61

SP - R25-R41

JO - Journal of Molecular Endocrinology

JF - Journal of Molecular Endocrinology

SN - 0952-5041

IS - 1

ER -