A method for assessing nonlinear growth in the fetal cortex

Rosita Shishegar, Joanne M. Britto, Leigh A. Johnston

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The cerebral cortex is folded into gyri and sulci in the brains of higher mammals. Quantitative study of the process by which the cortex folds during brain development is critical to a complete understanding of normal brain development and neuro-developmental disorders. In this work, we propose a new method by which to localise nonlinearities in the cortical folding process, and thereby identify regions of differential growth across the cortex. Our method is based on spherical harmonic (SPHARM) representation of the cortical surface. Linearity is assessed by comparison of each SPHARM reconstructed surface with an artificial surface constructed using a linear combination of SPHARM coefficients from data at adjoining developmental time points. The resultant quantification of cortical folding development is easy to interpret, and the method has low computational cost. We demonstrate application to a set of experimental MRI data of fetal sheep brains, across key developmental timepoints as the cortex first folds during development.

Original languageEnglish
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
EditorsJeff Duerk, Jim Ji
Place of PublicationPiscataway NJ USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages4
ISBN (Electronic)9781424479290
ISBN (Print)9781424479276
Publication statusPublished - 2014
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2014 - Sheraton Chicago Hotel and Towers, Chicago, United States of America
Duration: 26 Aug 201430 Aug 2014
Conference number: 36th
https://ieeexplore-ieee-org.ezproxy.lib.monash.edu.au/xpl/conhome/6923026/proceeding (Proceedings)
https://web.archive.org/web/20140331105330/http://embc.embs.org/2014/?page_id=120 (Website)


ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2014
Abbreviated titleEMBC 2014
Country/TerritoryUnited States of America
Internet address

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