A mathematical model of Chlamydial infection incorporating movement of Chlamydial particles

Dann G. Mallet; Masoumeh Bagher-Oskouei; A. Charisse Farr; Daniel P. Simpson; Kelly Jean Sutton

doi:10.1007/s11538-013-9891-9

A mathematical model of Chlamydial infection incorporating movement of Chlamydial particles

Dann G. Mallet, Masoumeh Bagher-Oskouei, A. Charisse Farr, Daniel P. Simpson, Kelly Jean Sutton

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

We present a spatiotemporal mathematical model of chlamydial infection, host immune response, and movement of infectious particles. The resulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous Chlamydia modelling by incorporating spatial change. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility.

Original language	English
Pages (from-to)	2257-2270
Number of pages	14
Journal	Bulletin of Mathematical Biology
Volume	75
Issue number	11
DOIs	https://doi.org/10.1007/s11538-013-9891-9
Publication status	Published - Nov 2013
Externally published	Yes

Keywords

Chlamydia trachomatis
Infectious diseases
Partial differential equation
Treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11538-013-9891-9

Cite this

@article{30403cf88c1f4162be74f9fa268ddc5d,

title = "A mathematical model of Chlamydial infection incorporating movement of Chlamydial particles",

abstract = "We present a spatiotemporal mathematical model of chlamydial infection, host immune response, and movement of infectious particles. The resulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous Chlamydia modelling by incorporating spatial change. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility.",

keywords = "Chlamydia trachomatis, Infectious diseases, Partial differential equation, Treatment",

author = "Mallet, {Dann G.} and Masoumeh Bagher-Oskouei and Farr, {A. Charisse} and Simpson, {Daniel P.} and Sutton, {Kelly Jean}",

year = "2013",

month = nov,

doi = "10.1007/s11538-013-9891-9",

language = "English",

volume = "75",

pages = "2257--2270",

journal = "Bulletin of Mathematical Biology",

issn = "0092-8240",

publisher = "Springer-Verlag London Ltd.",

number = "11",

}

TY - JOUR

T1 - A mathematical model of Chlamydial infection incorporating movement of Chlamydial particles

AU - Mallet, Dann G.

AU - Bagher-Oskouei, Masoumeh

AU - Farr, A. Charisse

AU - Simpson, Daniel P.

AU - Sutton, Kelly Jean

PY - 2013/11

Y1 - 2013/11

N2 - We present a spatiotemporal mathematical model of chlamydial infection, host immune response, and movement of infectious particles. The resulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous Chlamydia modelling by incorporating spatial change. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility.

AB - We present a spatiotemporal mathematical model of chlamydial infection, host immune response, and movement of infectious particles. The resulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous Chlamydia modelling by incorporating spatial change. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility.

KW - Chlamydia trachomatis

KW - Infectious diseases

KW - Partial differential equation

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=84892889520&partnerID=8YFLogxK

U2 - 10.1007/s11538-013-9891-9

DO - 10.1007/s11538-013-9891-9

M3 - Article

C2 - 24091779

AN - SCOPUS:84892889520

SN - 0092-8240

VL - 75

SP - 2257

EP - 2270

JO - Bulletin of Mathematical Biology

JF - Bulletin of Mathematical Biology

IS - 11

ER -

A mathematical model of Chlamydial infection incorporating movement of Chlamydial particles

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Cite this