A mathematical model for genetic regulation of the lactose operon

Tianhai Tian, Kevin Burrage

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4 Citations (Scopus)

Abstract

In this paper we construct a mathematical model for the genetic regulatory network of the lactose operon. This mathematical model contains transcription and translation of the lactose permease (LacY) and a reporter gene GFP. The probability of transcription of LacY is determined by 14 binding states out of all 50 possible binding states of the lactose operon based on the quasi-steady-state assumption for the binding reactions, while we calculate the probability of transcription for the reporter gene GFP based on 5 binding states out of 19 possible binding states because the binding site O2 is missing for this reporter gene. We have tested different mechanisms for the transport of thio-methylgalactoside (TMG) and the effect of different Hill coefficients on the simulated LacY expression levels. Using this mathematical model we have realized one of the experimental results with different LacY concentrations, which are induced by different concentrations of TMG.
Original languageEnglish
Title of host publicationComputational Science and Its Applications ICCSA 2005
EditorsM L Gavrilova, O Gervasi, V Kumar, A Lagana, H P Lee, Y Mun, D Taniar
Place of PublicationGermany
PublisherSpringer
Pages1245 - 1253
Number of pages9
ISBN (Print)0302-9743
DOIs
Publication statusPublished - 2005
Externally publishedYes
EventInternational Conference on Computational Science and Applications 2005 - Singapore, Germany
Duration: 1 Jan 2005 → …

Conference

ConferenceInternational Conference on Computational Science and Applications 2005
Abbreviated titleICCSA 2005
CityGermany
Period1/01/05 → …

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