A leucine–macrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets

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Although obesity is associated with higher risk of cardiometabolic disease, high-protein diets can reduce fatness but still promote cardiometabolic disease. Zhang et al. address this contradiction and show that high-protein diets, and subsequently higher blood leucine levels, promote mTORC1 activation in macrophages in humans and mice, and that an increase in dietary leucine raises the risk of atherosclerosis in a mouse model.

Original languageEnglish
Pages (from-to)203-204
Number of pages2
JournalNature Metabolism
Issue number2
Publication statusPublished - Feb 2024

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