A lateral gating mechanism is central to the operation of the Translocation and Assembly Module

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The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.
Original languageEnglish
Publication statusPublished - 11 Jul 2019
EventEMBO|EMBL Symposium 2019 - EMBL Heidelberg, Heidelberg, Germany
Duration: 10 Jul 201913 Jul 2019


ConferenceEMBO|EMBL Symposium 2019
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