The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.
|Publication status||Published - 11 Jul 2019|
|Event||EMBO|EMBL Symposium 2019: New Approaches and Concepts in Microbiology - EMBL Heidelberg, Heidelberg, Germany|
Duration: 10 Jul 2019 → 13 Jul 2019
|Conference||EMBO|EMBL Symposium 2019|
|Period||10/07/19 → 13/07/19|