The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.
|Publication status||Published - 22 Jun 2019|
|Event||Gordon Research Seminar on Mechanisms of Membrane Transport: Dynamics and Allosteric Regulation of Membrane Transport - Colby-Sawyer College, 541 Main Street, New London, United States of America|
Duration: 22 Jun 2019 → 23 Jun 2019
|Seminar||Gordon Research Seminar on Mechanisms of Membrane Transport|
|Abbreviated title||Mechanisms of Membrane Transport (GRS)|
|Country||United States of America|
|Period||22/06/19 → 23/06/19|