A lateral gating mechanism is central to the operation of the Translocation and Assembly Module

Research output: Contribution to conferencePosterOther

Abstract

The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.
Original languageEnglish
Publication statusPublished - 26 Jun 2019
EventGordon Research Conference on Mechanisms of Membrane Transport: Folding and Evolution in the Membrane Environment: New Ways of Understanding Transport Mechanisms - Colby-Sawyer College, 541 Main Street, New London, United States of America
Duration: 23 Jun 201928 Jun 2019
https://www.grc.org/mechanisms-of-membrane-transport-conference/2019/

Conference

ConferenceGordon Research Conference on Mechanisms of Membrane Transport
Abbreviated titleMechanisms of Membrane Transport
CountryUnited States of America
CityNew London
Period23/06/1928/06/19
Internet address

Cite this

Stubenrauch, C. (2019). A lateral gating mechanism is central to the operation of the Translocation and Assembly Module. Poster session presented at Gordon Research Conference on Mechanisms of Membrane Transport, New London, United States of America.
Stubenrauch, Christopher. / A lateral gating mechanism is central to the operation of the Translocation and Assembly Module. Poster session presented at Gordon Research Conference on Mechanisms of Membrane Transport, New London, United States of America.
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title = "A lateral gating mechanism is central to the operation of the Translocation and Assembly Module",
abstract = "The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.",
author = "Christopher Stubenrauch",
note = "This is the main conference portion of the Mechanisms of Membrane Transport, following on from the student/post-doc seminar of the same title. My work was presented over two days, beginning Wednesday 26 June, 2019 - this same work was showcased during the seminar component as well.; Gordon Research Conference on Mechanisms of Membrane Transport : Folding and Evolution in the Membrane Environment: New Ways of Understanding Transport Mechanisms, Mechanisms of Membrane Transport ; Conference date: 23-06-2019 Through 28-06-2019",
year = "2019",
month = "6",
day = "26",
language = "English",
url = "https://www.grc.org/mechanisms-of-membrane-transport-conference/2019/",

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Stubenrauch, C 2019, 'A lateral gating mechanism is central to the operation of the Translocation and Assembly Module' Gordon Research Conference on Mechanisms of Membrane Transport, New London, United States of America, 23/06/19 - 28/06/19, .

A lateral gating mechanism is central to the operation of the Translocation and Assembly Module. / Stubenrauch, Christopher.

2019. Poster session presented at Gordon Research Conference on Mechanisms of Membrane Transport, New London, United States of America.

Research output: Contribution to conferencePosterOther

TY - CONF

T1 - A lateral gating mechanism is central to the operation of the Translocation and Assembly Module

AU - Stubenrauch, Christopher

N1 - This is the main conference portion of the Mechanisms of Membrane Transport, following on from the student/post-doc seminar of the same title. My work was presented over two days, beginning Wednesday 26 June, 2019 - this same work was showcased during the seminar component as well.

PY - 2019/6/26

Y1 - 2019/6/26

N2 - The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.

AB - The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.

M3 - Poster

ER -

Stubenrauch C. A lateral gating mechanism is central to the operation of the Translocation and Assembly Module. 2019. Poster session presented at Gordon Research Conference on Mechanisms of Membrane Transport, New London, United States of America.