The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.
|Publication status||Published - 26 Jun 2019|
|Event||Gordon Research Conference on Mechanisms of Membrane Transport: Folding and Evolution in the Membrane Environment: New Ways of Understanding Transport Mechanisms - Colby-Sawyer College, 541 Main Street, New London, United States of America|
Duration: 23 Jun 2019 → 28 Jun 2019
|Conference||Gordon Research Conference on Mechanisms of Membrane Transport|
|Abbreviated title||Mechanisms of Membrane Transport|
|Country||United States of America|
|Period||23/06/19 → 28/06/19|
Stubenrauch, C. (2019). A lateral gating mechanism is central to the operation of the Translocation and Assembly Module. Poster session presented at Gordon Research Conference on Mechanisms of Membrane Transport, New London, United States of America.