A lateral gating mechanism is central to the operation of the Translocation and Assembly Module

Christopher Stubenrauch

A lateral gating mechanism is central to the operation of the Translocation and Assembly Module

Research output: Contribution to conference › Poster

Abstract

The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.

Original language	English
Publication status	Published - 26 Jun 2019
Event	Gordon Research Conference on Mechanisms of Membrane Transport: Folding and Evolution in the Membrane Environment: New Ways of Understanding Transport Mechanisms - Colby-Sawyer College, 541 Main Street, New London, United States of America Duration: 23 Jun 2019 → 28 Jun 2019 https://www.grc.org/mechanisms-of-membrane-transport-conference/2019/

Conference

Conference	Gordon Research Conference on Mechanisms of Membrane Transport
Abbreviated title	Mechanisms of Membrane Transport
Country/Territory	United States of America
City	New London
Period	23/06/19 → 28/06/19
Internet address	https://www.grc.org/mechanisms-of-membrane-transport-conference/2019/

1 Poster

A lateral gating mechanism is central to the operation of the Translocation and Assembly Module
Stubenrauch, C., 22 Jun 2019.
Research output: Contribution to conference › Poster

ASBMB Fellowship
Stubenrauch, Chris (Recipient), 30 Mar 2019
Prize: Prize (including medals and awards)
Fred Collins Award
Stubenrauch, Chris (Recipient), 30 Mar 2019
Prize: Prize (including medals and awards)

Cite this

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title = "A lateral gating mechanism is central to the operation of the Translocation and Assembly Module",

abstract = "The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.",

author = "Christopher Stubenrauch",

note = "This is the main conference portion of the Mechanisms of Membrane Transport, following on from the student/post-doc seminar of the same title. My work was presented over two days, beginning Wednesday 26 June, 2019 - this same work was showcased during the seminar component as well.; Gordon Research Conference on Mechanisms of Membrane Transport : Folding and Evolution in the Membrane Environment: New Ways of Understanding Transport Mechanisms, Mechanisms of Membrane Transport ; Conference date: 23-06-2019 Through 28-06-2019",

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N1 - This is the main conference portion of the Mechanisms of Membrane Transport, following on from the student/post-doc seminar of the same title. My work was presented over two days, beginning Wednesday 26 June, 2019 - this same work was showcased during the seminar component as well.

PY - 2019/6/26

Y1 - 2019/6/26

N2 - The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.

AB - The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.

M3 - Poster

T2 - Gordon Research Conference on Mechanisms of Membrane Transport

Y2 - 23 June 2019 through 28 June 2019

ER -

A lateral gating mechanism is central to the operation of the Translocation and Assembly Module

Abstract

Conference

Research output

A lateral gating mechanism is central to the operation of the Translocation and Assembly Module

Prizes

ASBMB Fellowship

Fred Collins Award

Cite this