A lateral gating mechanism is central to the operation of the Translocation and Assembly Module

Research output: Contribution to conferencePoster


The vast majority of integral membrane proteins residing within the outer membrane of Gram-negative bacteria adopt a β-barrel architecture. Mechanistically, how these proteins fold remains uncertain, but the process requires a number of protein nanomachines, including the translocation and assembly module (TAM). The TAM is comprised of two subunits: TamA, an integral outer membrane protein, and TamB, an inner membrane-anchored protein, and the following data suggests the TAM utilises a lateral gating mechanism to fold substrate proteins.
Original languageEnglish
Publication statusPublished - 26 Jun 2019
EventGordon Research Conference on Mechanisms of Membrane Transport: Folding and Evolution in the Membrane Environment: New Ways of Understanding Transport Mechanisms - Colby-Sawyer College, 541 Main Street, New London, United States of America
Duration: 23 Jun 201928 Jun 2019


ConferenceGordon Research Conference on Mechanisms of Membrane Transport
Abbreviated titleMechanisms of Membrane Transport
Country/TerritoryUnited States of America
CityNew London
Internet address

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