A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer

Samuel J. Rodgers; Sabryn A. Hamila; Christina A. Mitchell; Lisa M. Ooms

doi:10.1080/23723556.2021.1954470

A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer

Samuel J. Rodgers, Sabryn A. Hamila, Christina A. Mitchell, Lisa M. Ooms

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER⁺) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characterized. We discovered that a subset of PIK3CA-mutant ER⁺ breast cancers exhibit increased inositol polyphosphate 4-phosphatase type II (INPP4B) expression, which promotes late endosome formation and glycogen synthase kinase 3 beta (GSK3β) trafficking, leading to enhanced Wingless–related integration site (WNT)/catenin beta 1 (β-catenin) activation.

Original language	English
Article number	1954470
Number of pages	3
Journal	Molecular and Cellular Oncology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2021.1954470
Publication status	Published - 2021

Keywords

cell proliferation
INPP4B
late endosome
PIK3CA
WNT/β-catenin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2021.1954470

Cite this

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title = "A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer",

abstract = "AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characterized. We discovered that a subset of PIK3CA-mutant ER+ breast cancers exhibit increased inositol polyphosphate 4-phosphatase type II (INPP4B) expression, which promotes late endosome formation and glycogen synthase kinase 3 beta (GSK3β) trafficking, leading to enhanced Wingless–related integration site (WNT)/catenin beta 1 (β-catenin) activation.",

keywords = "cell proliferation, INPP4B, late endosome, PIK3CA, WNT/β-catenin",

author = "Rodgers, \{Samuel J.\} and Hamila, \{Sabryn A.\} and Mitchell, \{Christina A.\} and Ooms, \{Lisa M.\}",

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year = "2021",

doi = "10.1080/23723556.2021.1954470",

language = "English",

volume = "8",

journal = "Molecular and Cellular Oncology",

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T1 - A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer

AU - Rodgers, Samuel J.

AU - Hamila, Sabryn A.

AU - Mitchell, Christina A.

AU - Ooms, Lisa M.

PY - 2021

Y1 - 2021

N2 - AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characterized. We discovered that a subset of PIK3CA-mutant ER+ breast cancers exhibit increased inositol polyphosphate 4-phosphatase type II (INPP4B) expression, which promotes late endosome formation and glycogen synthase kinase 3 beta (GSK3β) trafficking, leading to enhanced Wingless–related integration site (WNT)/catenin beta 1 (β-catenin) activation.

AB - AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characterized. We discovered that a subset of PIK3CA-mutant ER+ breast cancers exhibit increased inositol polyphosphate 4-phosphatase type II (INPP4B) expression, which promotes late endosome formation and glycogen synthase kinase 3 beta (GSK3β) trafficking, leading to enhanced Wingless–related integration site (WNT)/catenin beta 1 (β-catenin) activation.

KW - cell proliferation

KW - INPP4B

KW - late endosome

KW - PIK3CA

KW - WNT/β-catenin

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DO - 10.1080/23723556.2021.1954470

M3 - Article

C2 - 34616876

AN - SCOPUS:85114621399

SN - 2372-3556

VL - 8

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 4

M1 - 1954470

ER -

A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer

Abstract

Keywords

UN SDGs

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Other files and links

Characterisation of a novel oncogene in breast cancer

Cite this

A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Characterisation of a novel oncogene in breast cancer

Cite this