A label-free, quantitative Fecal Hemoglobin detection platform for colorectal cancer screening

Gita V. Soraya, Thanh C. Nguyen, Chathurika D. Abeyrathne, Duc H. Huynh, Jianxiong Chan, Phuong D. Nguyen, Babak Nasr, Gursharan Chana, Patrick Kwan, Efstratios Skafidas

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings. The label-free prototype has a lower limit of detection (LOD) of 10 μg hemoglobin per gram (Hb/g) of feces, comparable to that of conventional laboratory based quantitative FIT diagnostic systems.

Original languageEnglish
Article number19
Number of pages11
JournalBiosensors
Volume7
Issue number2
DOIs
Publication statusPublished - 1 May 2017
Externally publishedYes

Keywords

  • Biosensors
  • Colorectal cancer
  • Diagnostics
  • Immunosensor
  • Impedance
  • Interdigitated electrodes
  • Label-free
  • Point of care
  • Screening

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