A hypothesis to phenotype COPD exacerbations by aetiology

Martin MacDonald, Richard Beasley, Louis Irving, Philip Bardin

Research output: Contribution to journalArticleOther

20 Citations (Scopus)


COPD exacerbations have traditionally been defined on the basis of symptoms or health-care utilization without specific reference to the suspected aetiology. Consequently, the term exacerbation has been used to include all patients experiencing an acute deterioration of symptoms associated with COPD. However, exacerbations are known to result from a variety of causes and do not necessarily constitute an equivalent event in the same patient, between different patients or between individual research studies. We therefore hypothesize that phenotyping exacerbations by aetiology may identify exacerbation subgroups, clarify benefits of therapeutic intervention in the subgroups and overall improve clinical care. An acronym is proposed to facilitate phenotyping COPD exacerbations.
Original languageEnglish
Pages (from-to)264 - 268
Number of pages5
Issue number2
Publication statusPublished - 2011

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