A hyperelastic model for mechanical responses of adherent cells in microinjection

Tianyao Shen; Bijan Shirinzadeh; Yongmin Zhong; Julian Smith

doi:10.1109/3M-NANO.2017.8286266

A hyperelastic model for mechanical responses of adherent cells in microinjection

Tianyao Shen
, Bijan Shirinzadeh
, Yongmin Zhong
, Julian Smith

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

4 Citations (Scopus)

Abstract

Single cell microinjection is widely used in biological sciences, especially in genetic engineering and cytopathology. To investigate mechanical responses of the adherent cell in microinjection, a general geometrical description of adherent cells in microinjection is proposed. Based on finite strain theory in isotropic hyperelasticity and minimal potential energy principle, a hyperelastic model of the adherent cell is developed. Factors affecting the interaction force and the stress distribution in the adherent cell penetration are revealed and analyzed. The force-deformation relationship obtained in the proposed model shows high similarity with classical Hertz model, while more detailed mechanical behaviours of the adherent cell in microinjection can be discovered from the proposed model.

Original language	English
Title of host publication	Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	289-294
Number of pages	6
ISBN (Electronic)	9781538610817
DOIs	https://doi.org/10.1109/3M-NANO.2017.8286266
Publication status	Published - 7 Feb 2018
Event	International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (M-NANO) 2017 - The Longemont Hotel, Shanghai, China Duration: 7 Aug 2017 → 11 Aug 2017 Conference number: 7th http://www.3m-nano.org/2017/main/index.asp

Publication series

Name	Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017
Volume	2018-January

Conference

Conference	International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (M-NANO) 2017
Abbreviated title	3M-NANO 2017
Country/Territory	China
City	Shanghai
Period	7/08/17 → 11/08/17
Internet address	http://www.3m-nano.org/2017/main/index.asp

Keywords

Adherent cells
Hyperelastic
Mechanical responses
Microinjection

Access to Document

10.1109/3M-NANO.2017.8286266

Cite this

Shen, T., Shirinzadeh, B., Zhong, Y., & Smith, J. (2018). A hyperelastic model for mechanical responses of adherent cells in microinjection. In Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017 (pp. 289-294). (Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017; Vol. 2018-January). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/3M-NANO.2017.8286266

Shen, Tianyao ; Shirinzadeh, Bijan ; Zhong, Yongmin et al. / A hyperelastic model for mechanical responses of adherent cells in microinjection. Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017. IEEE, Institute of Electrical and Electronics Engineers, 2018. pp. 289-294 (Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017).

@inproceedings{f6df3d1141fd4392a6b2b699ee70d8e5,

title = "A hyperelastic model for mechanical responses of adherent cells in microinjection",

abstract = "Single cell microinjection is widely used in biological sciences, especially in genetic engineering and cytopathology. To investigate mechanical responses of the adherent cell in microinjection, a general geometrical description of adherent cells in microinjection is proposed. Based on finite strain theory in isotropic hyperelasticity and minimal potential energy principle, a hyperelastic model of the adherent cell is developed. Factors affecting the interaction force and the stress distribution in the adherent cell penetration are revealed and analyzed. The force-deformation relationship obtained in the proposed model shows high similarity with classical Hertz model, while more detailed mechanical behaviours of the adherent cell in microinjection can be discovered from the proposed model.",

keywords = "Adherent cells, Hyperelastic, Mechanical responses, Microinjection",

author = "Tianyao Shen and Bijan Shirinzadeh and Yongmin Zhong and Julian Smith",

year = "2018",

month = feb,

day = "7",

doi = "10.1109/3M-NANO.2017.8286266",

language = "English",

series = "Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

pages = "289--294",

booktitle = "Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017",

address = "United States of America",

note = "International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (M-NANO) 2017, 3M-NANO 2017 ; Conference date: 07-08-2017 Through 11-08-2017",

url = "http://www.3m-nano.org/2017/main/index.asp",

}

Shen, T, Shirinzadeh, B, Zhong, Y & Smith, J 2018, A hyperelastic model for mechanical responses of adherent cells in microinjection. in Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017. Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017, vol. 2018-January, IEEE, Institute of Electrical and Electronics Engineers, pp. 289-294, International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (M-NANO) 2017, Shanghai, China, 7/08/17. https://doi.org/10.1109/3M-NANO.2017.8286266

A hyperelastic model for mechanical responses of adherent cells in microinjection. / Shen, Tianyao; Shirinzadeh, Bijan; Zhong, Yongmin et al.
Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017. IEEE, Institute of Electrical and Electronics Engineers, 2018. p. 289-294 (Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017; Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

TY - GEN

T1 - A hyperelastic model for mechanical responses of adherent cells in microinjection

AU - Shen, Tianyao

AU - Shirinzadeh, Bijan

AU - Zhong, Yongmin

AU - Smith, Julian

N1 - Conference code: 7th

PY - 2018/2/7

Y1 - 2018/2/7

N2 - Single cell microinjection is widely used in biological sciences, especially in genetic engineering and cytopathology. To investigate mechanical responses of the adherent cell in microinjection, a general geometrical description of adherent cells in microinjection is proposed. Based on finite strain theory in isotropic hyperelasticity and minimal potential energy principle, a hyperelastic model of the adherent cell is developed. Factors affecting the interaction force and the stress distribution in the adherent cell penetration are revealed and analyzed. The force-deformation relationship obtained in the proposed model shows high similarity with classical Hertz model, while more detailed mechanical behaviours of the adherent cell in microinjection can be discovered from the proposed model.

AB - Single cell microinjection is widely used in biological sciences, especially in genetic engineering and cytopathology. To investigate mechanical responses of the adherent cell in microinjection, a general geometrical description of adherent cells in microinjection is proposed. Based on finite strain theory in isotropic hyperelasticity and minimal potential energy principle, a hyperelastic model of the adherent cell is developed. Factors affecting the interaction force and the stress distribution in the adherent cell penetration are revealed and analyzed. The force-deformation relationship obtained in the proposed model shows high similarity with classical Hertz model, while more detailed mechanical behaviours of the adherent cell in microinjection can be discovered from the proposed model.

KW - Adherent cells

KW - Hyperelastic

KW - Mechanical responses

KW - Microinjection

UR - https://www.scopus.com/pages/publications/85047426121

U2 - 10.1109/3M-NANO.2017.8286266

DO - 10.1109/3M-NANO.2017.8286266

M3 - Conference Paper

AN - SCOPUS:85047426121

T3 - Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017

SP - 289

EP - 294

BT - Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017

PB - IEEE, Institute of Electrical and Electronics Engineers

T2 - International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (M-NANO) 2017

Y2 - 7 August 2017 through 11 August 2017

ER -

Shen T, Shirinzadeh B, Zhong Y, Smith J. A hyperelastic model for mechanical responses of adherent cells in microinjection. In Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017. IEEE, Institute of Electrical and Electronics Engineers. 2018. p. 289-294. (Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017). doi: 10.1109/3M-NANO.2017.8286266

A hyperelastic model for mechanical responses of adherent cells in microinjection

Abstract

Publication series

Conference

Keywords

Access to Document

Other files and links

Cite this