A hyperelastic model for mechanical responses of adherent cells in microinjection

Tianyao Shen, Bijan Shirinzadeh, Yongmin Zhong, Julian Smith

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

1 Citation (Scopus)

Abstract

Single cell microinjection is widely used in biological sciences, especially in genetic engineering and cytopathology. To investigate mechanical responses of the adherent cell in microinjection, a general geometrical description of adherent cells in microinjection is proposed. Based on finite strain theory in isotropic hyperelasticity and minimal potential energy principle, a hyperelastic model of the adherent cell is developed. Factors affecting the interaction force and the stress distribution in the adherent cell penetration are revealed and analyzed. The force-deformation relationship obtained in the proposed model shows high similarity with classical Hertz model, while more detailed mechanical behaviours of the adherent cell in microinjection can be discovered from the proposed model.

Original languageEnglish
Title of host publicationConference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages289-294
Number of pages6
ISBN (Electronic)9781538610817
DOIs
Publication statusPublished - 7 Feb 2018
EventInternational Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (M-NANO) 2017 - The Longemont Hotel, Shanghai, China
Duration: 7 Aug 201711 Aug 2017
Conference number: 7th
http://www.3m-nano.org/2017/main/index.asp

Publication series

NameConference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017
Volume2018-January

Conference

ConferenceInternational Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (M-NANO) 2017
Abbreviated title3M-NANO 2017
CountryChina
CityShanghai
Period7/08/1711/08/17
Internet address

Keywords

  • Adherent cells
  • Hyperelastic
  • Mechanical responses
  • Microinjection

Cite this

Shen, T., Shirinzadeh, B., Zhong, Y., & Smith, J. (2018). A hyperelastic model for mechanical responses of adherent cells in microinjection. In Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017 (pp. 289-294). (Conference Program Digest - 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2017; Vol. 2018-January). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/3M-NANO.2017.8286266