A hybrid intelligent model for acute hypotensive episode prediction with large-scale data

Acute hypotensive episode (AHE) is a common serious postoperative complication in ICU, which may raise multiple system failure (especially of cardiac and respiratory kinds), and even cause death. Timely and effective clinical intervention is obviously vital to the saving of patients. AHE detection involves physiological time-series monitoring, processing and prediction technologies, which can offer insights to neuroscientists, biologists, and even provide support for clinicians. This paper presents a hybrid artificial intelligence model combined with CEEMDAN (complete ensemble empirical mode decomposition with adaptive noise, a typical method for physiological signal decomposition), deep learning, multiple gene expression programming and fuzzy expert system for AHE detection. In this paper, the physiological signal is selected from a benchmark dataset, for example MIMIC-II (Multiparameter Intelligent Monitoring in Intensive Care II), which collects large scale real patients’ data for clinical research. In the hybrid model, a typical signal decomposition method is employed for AHE signal processing, and an autoencoder based deep neural network is established for feature extraction. Finally, a reliable and explainable classifier is presented by fusing gene expression programming and the fuzzy method. Experimental results based on real data set demonstrate that the proposed method outperforms state-of-the-art AHE detection methods by achieving the prediction accuracy of 88.14% in 2866 records.