A highly enantioselective synthesis of cyclic α-amino acids involving a one-pot, single catalyst, tandem hydrogenation-hydroformylation sequence

Ching Mei Teoh; Eva M Campi; William Roy Jackson; Andrea J Robinson

doi:10.1039/b200374k

A highly enantioselective synthesis of cyclic α-amino acids involving a one-pot, single catalyst, tandem hydrogenation-hydroformylation sequence

Ching Mei Teoh, Eva M Campi, William Roy Jackson, Andrea J Robinson

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

41 Citations (Scopus)

Abstract

Tandem enantioselective hydrogenation followed by a hydroformylation-cyclisation sequence leading to cyclic α-amino acids with ee’s >95% can be achieved in a single pot, one catalyst system by successive reactions of prochiral dienamide esters with H₂ followed by H₂/CO using Rh(i)-DuPHOS.

Original language	English
Pages (from-to)	978-979
Number of pages	2
Journal	Chemical Communications
Volume	2
Issue number	9
DOIs	https://doi.org/10.1039/b200374k
Publication status	Published - 1 Jan 2002

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abstract = "Tandem enantioselective hydrogenation followed by a hydroformylation-cyclisation sequence leading to cyclic α-amino acids with ee{\textquoteright}s >95% can be achieved in a single pot, one catalyst system by successive reactions of prochiral dienamide esters with H2 followed by H2/CO using Rh(i)-DuPHOS.",

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AU - Robinson, Andrea J

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AB - Tandem enantioselective hydrogenation followed by a hydroformylation-cyclisation sequence leading to cyclic α-amino acids with ee’s >95% can be achieved in a single pot, one catalyst system by successive reactions of prochiral dienamide esters with H2 followed by H2/CO using Rh(i)-DuPHOS.

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A highly enantioselective synthesis of cyclic α-amino acids involving a one-pot, single catalyst, tandem hydrogenation-hydroformylation sequence

Abstract

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