A genome-wide association study of metabolic traits in human urine

Karsten Suhre; Henri Wallaschofski; Johannes Raffler; Nele Friedrich; Robin Haring; Kathrin Michael; Christina Wasner; Alexander Krebs; Florian Kronenberg; Christa Meisinger; H. Erich Wichmann; Wolfgang Hoffmann; Henry Völzke; Uwe Völker; Alexander Teumer; Reiner Biffar; Thomas Kocher; Stephan B. Felix; Thomas Illig; Heyo K. Kroemer; Christian Gieger; Werner Römisch-Margl; Matthias Nauck

doi:10.1038/ng.837

A genome-wide association study of metabolic traits in human urine

Karsten Suhre, Henri Wallaschofski, Johannes Raffler, Nele Friedrich, Robin Haring, Kathrin Michael, Christina Wasner, Alexander Krebs, Florian Kronenberg, Christa Meisinger, H. Erich Wichmann, Wolfgang Hoffmann, Henry Völzke, Uwe Völker, Alexander Teumer, Reiner Biffar, Thomas Kocher, Stephan B. Felix, Thomas Illig, Heyo K. KroemerChristian Gieger, Werner Römisch-Margl, Matthias Nauck

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

We present a genome-wide association study of metabolic traits in human urine, designed to investigate the detoxification capacity of the human body. Using NMR spectroscopy, we tested for associations between 59 metabolites in urine from 862 male participants in the population-based SHIP study. We replicated the results using 1,039 additional samples of the same study, including a 5-year follow-up, and 992 samples from the independent KORA study. We report five loci with joint P values of association from 3.2 × 10- ¹⁹ to 2.1 × 10-182. Variants at three of these loci have previously been linked with important clinical outcomes: SLC7A9 is a risk locus for chronic kidney disease, NAT2 for coronary artery disease and genotype-dependent response to drug toxicity, and SLC6A20 for iminoglycinuria. Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper- 2-aminoisobutyric aciduria.

Original language	English
Pages (from-to)	565-569
Number of pages	5
Journal	Nature Genetics
Volume	43
Issue number	6
DOIs	https://doi.org/10.1038/ng.837
Publication status	Published - Jun 2011
Externally published	Yes

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Suhre, K., Wallaschofski, H., Raffler, J., Friedrich, N., Haring, R., Michael, K., Wasner, C., Krebs, A., Kronenberg, F., Meisinger, C., Wichmann, H. E., Hoffmann, W., Völzke, H., Völker, U., Teumer, A., Biffar, R., Kocher, T., Felix, S. B., Illig, T., ... Nauck, M. (2011). A genome-wide association study of metabolic traits in human urine. Nature Genetics, 43(6), 565-569. https://doi.org/10.1038/ng.837

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title = "A genome-wide association study of metabolic traits in human urine",

abstract = "We present a genome-wide association study of metabolic traits in human urine, designed to investigate the detoxification capacity of the human body. Using NMR spectroscopy, we tested for associations between 59 metabolites in urine from 862 male participants in the population-based SHIP study. We replicated the results using 1,039 additional samples of the same study, including a 5-year follow-up, and 992 samples from the independent KORA study. We report five loci with joint P values of association from 3.2 × 10- 19 to 2.1 × 10-182. Variants at three of these loci have previously been linked with important clinical outcomes: SLC7A9 is a risk locus for chronic kidney disease, NAT2 for coronary artery disease and genotype-dependent response to drug toxicity, and SLC6A20 for iminoglycinuria. Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper- 2-aminoisobutyric aciduria.",

author = "Karsten Suhre and Henri Wallaschofski and Johannes Raffler and Nele Friedrich and Robin Haring and Kathrin Michael and Christina Wasner and Alexander Krebs and Florian Kronenberg and Christa Meisinger and Wichmann, {H. Erich} and Wolfgang Hoffmann and Henry V{\"o}lzke and Uwe V{\"o}lker and Alexander Teumer and Reiner Biffar and Thomas Kocher and Felix, {Stephan B.} and Thomas Illig and Kroemer, {Heyo K.} and Christian Gieger and Werner R{\"o}misch-Margl and Matthias Nauck",

year = "2011",

month = jun,

doi = "10.1038/ng.837",

language = "English",

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Suhre, K, Wallaschofski, H, Raffler, J, Friedrich, N, Haring, R, Michael, K, Wasner, C, Krebs, A, Kronenberg, F, Meisinger, C, Wichmann, HE, Hoffmann, W, Völzke, H, Völker, U, Teumer, A, Biffar, R, Kocher, T, Felix, SB, Illig, T, Kroemer, HK, Gieger, C, Römisch-Margl, W & Nauck, M 2011, 'A genome-wide association study of metabolic traits in human urine', Nature Genetics, vol. 43, no. 6, pp. 565-569. https://doi.org/10.1038/ng.837

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AU - Suhre, Karsten

AU - Wallaschofski, Henri

AU - Raffler, Johannes

AU - Friedrich, Nele

AU - Haring, Robin

AU - Michael, Kathrin

AU - Wasner, Christina

AU - Krebs, Alexander

AU - Kronenberg, Florian

AU - Meisinger, Christa

AU - Wichmann, H. Erich

AU - Hoffmann, Wolfgang

AU - Völzke, Henry

AU - Völker, Uwe

AU - Teumer, Alexander

AU - Biffar, Reiner

AU - Kocher, Thomas

AU - Felix, Stephan B.

AU - Illig, Thomas

AU - Kroemer, Heyo K.

AU - Gieger, Christian

AU - Römisch-Margl, Werner

AU - Nauck, Matthias

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AB - We present a genome-wide association study of metabolic traits in human urine, designed to investigate the detoxification capacity of the human body. Using NMR spectroscopy, we tested for associations between 59 metabolites in urine from 862 male participants in the population-based SHIP study. We replicated the results using 1,039 additional samples of the same study, including a 5-year follow-up, and 992 samples from the independent KORA study. We report five loci with joint P values of association from 3.2 × 10- 19 to 2.1 × 10-182. Variants at three of these loci have previously been linked with important clinical outcomes: SLC7A9 is a risk locus for chronic kidney disease, NAT2 for coronary artery disease and genotype-dependent response to drug toxicity, and SLC6A20 for iminoglycinuria. Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper- 2-aminoisobutyric aciduria.

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EP - 569

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

A genome-wide association study of metabolic traits in human urine

Abstract

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