A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy

Doug Speed; Clive Hoggart; Slave Petrovski; Ioanna Tachmazidou; Alison Coffey; Andrea Jorgensen; Hariklia Eleftherohorinou; Maria De Iorio; Marian Todaro; Tisham De; David Smith; Philip E. Smith; Margaret Jackson; Paul Cooper; Mark Kellett; Stephen Howell; Mark Newton; Raju Yerra; Meng Tan; Chris French; Markus Reuber; Graeme E. Sills; David Chadwick; Munir Pirmohamed; David Bentley; Ingrid Scheffer; Samuel Berkovic; David Balding; Aarno Palotie; Anthony Marson; Terence J. O'Brien; Michael R. Johnson

doi:10.1093/hmg/ddt403

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy

Doug Speed, Clive Hoggart, Slave Petrovski, Ioanna Tachmazidou, Alison Coffey, Andrea Jorgensen, Hariklia Eleftherohorinou, Maria De Iorio, Marian Todaro, Tisham De, David Smith, Philip E. Smith, Margaret Jackson, Paul Cooper, Mark Kellett, Stephen Howell, Mark Newton, Raju Yerra, Meng Tan, Chris FrenchMarkus Reuber, Graeme E. Sills, David Chadwick, Munir Pirmohamed, David Bentley, Ingrid Scheffer, Samuel Berkovic, David Balding, Aarno Palotie, Anthony Marson, Terence J. O'Brien, Michael R. Johnson

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

Abstract

We present the analysis of a prospective multicentre study to investigate genetic effects on the prognosis of newly treated epilepsy. Patients with a new clinical diagnosis of epilepsy requiring medication were recruited and followed up prospectively. The clinical outcome was defined as freedom from seizures for a minimum of 12 months in accordance with the consensus statement from the International League Against Epilepsy (ILAE). Genetic effects on remission of seizures after starting treatment were analysed with and without adjustment for significant clinical prognostic factors, and the results from each cohort were combined using a fixedeffects meta-analysis. After quality control (QC), we analysed 889 newly treated epilepsy patients using 472 450.

Original language	English
Article number	ddt403
Pages (from-to)	247-258
Number of pages	12
Journal	Human Molecular Genetics
Volume	23
Issue number	1
DOIs	https://doi.org/10.1093/hmg/ddt403
Publication status	Published - Jan 2014
Externally published	Yes

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Speed, D., Hoggart, C., Petrovski, S., Tachmazidou, I., Coffey, A., Jorgensen, A., Eleftherohorinou, H., De Iorio, M., Todaro, M., De, T., Smith, D., Smith, P. E., Jackson, M., Cooper, P., Kellett, M., Howell, S., Newton, M., Yerra, R., Tan, M., ... Johnson, M. R. (2014). A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. Human Molecular Genetics, 23(1), 247-258. [ddt403]. https://doi.org/10.1093/hmg/ddt403

Speed, Doug ; Hoggart, Clive ; Petrovski, Slave ; Tachmazidou, Ioanna ; Coffey, Alison ; Jorgensen, Andrea ; Eleftherohorinou, Hariklia ; De Iorio, Maria ; Todaro, Marian ; De, Tisham ; Smith, David ; Smith, Philip E. ; Jackson, Margaret ; Cooper, Paul ; Kellett, Mark ; Howell, Stephen ; Newton, Mark ; Yerra, Raju ; Tan, Meng ; French, Chris ; Reuber, Markus ; Sills, Graeme E. ; Chadwick, David ; Pirmohamed, Munir ; Bentley, David ; Scheffer, Ingrid ; Berkovic, Samuel ; Balding, David ; Palotie, Aarno ; Marson, Anthony ; O'Brien, Terence J. ; Johnson, Michael R. / A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. In: Human Molecular Genetics. 2014 ; Vol. 23, No. 1. pp. 247-258.

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title = "A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy",

abstract = "We present the analysis of a prospective multicentre study to investigate genetic effects on the prognosis of newly treated epilepsy. Patients with a new clinical diagnosis of epilepsy requiring medication were recruited and followed up prospectively. The clinical outcome was defined as freedom from seizures for a minimum of 12 months in accordance with the consensus statement from the International League Against Epilepsy (ILAE). Genetic effects on remission of seizures after starting treatment were analysed with and without adjustment for significant clinical prognostic factors, and the results from each cohort were combined using a fixedeffects meta-analysis. After quality control (QC), we analysed 889 newly treated epilepsy patients using 472 450.",

author = "Doug Speed and Clive Hoggart and Slave Petrovski and Ioanna Tachmazidou and Alison Coffey and Andrea Jorgensen and Hariklia Eleftherohorinou and {De Iorio}, Maria and Marian Todaro and Tisham De and David Smith and Smith, {Philip E.} and Margaret Jackson and Paul Cooper and Mark Kellett and Stephen Howell and Mark Newton and Raju Yerra and Meng Tan and Chris French and Markus Reuber and Sills, {Graeme E.} and David Chadwick and Munir Pirmohamed and David Bentley and Ingrid Scheffer and Samuel Berkovic and David Balding and Aarno Palotie and Anthony Marson and O'Brien, {Terence J.} and Johnson, {Michael R.}",

year = "2014",

month = jan,

doi = "10.1093/hmg/ddt403",

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pages = "247--258",

journal = "Human Molecular Genetics",

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Speed, D, Hoggart, C, Petrovski, S, Tachmazidou, I, Coffey, A, Jorgensen, A, Eleftherohorinou, H, De Iorio, M, Todaro, M, De, T, Smith, D, Smith, PE, Jackson, M, Cooper, P, Kellett, M, Howell, S, Newton, M, Yerra, R, Tan, M, French, C, Reuber, M, Sills, GE, Chadwick, D, Pirmohamed, M, Bentley, D, Scheffer, I, Berkovic, S, Balding, D, Palotie, A, Marson, A, O'Brien, TJ & Johnson, MR 2014, 'A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy', Human Molecular Genetics, vol. 23, no. 1, ddt403, pp. 247-258. https://doi.org/10.1093/hmg/ddt403

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. / Speed, Doug; Hoggart, Clive; Petrovski, Slave; Tachmazidou, Ioanna; Coffey, Alison; Jorgensen, Andrea; Eleftherohorinou, Hariklia; De Iorio, Maria; Todaro, Marian; De, Tisham; Smith, David; Smith, Philip E.; Jackson, Margaret; Cooper, Paul; Kellett, Mark; Howell, Stephen; Newton, Mark; Yerra, Raju; Tan, Meng; French, Chris; Reuber, Markus; Sills, Graeme E.; Chadwick, David; Pirmohamed, Munir; Bentley, David; Scheffer, Ingrid; Berkovic, Samuel; Balding, David; Palotie, Aarno; Marson, Anthony; O'Brien, Terence J.; Johnson, Michael R.

In: Human Molecular Genetics, Vol. 23, No. 1, ddt403, 01.2014, p. 247-258.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Hoggart, Clive

AU - Petrovski, Slave

AU - Tachmazidou, Ioanna

AU - Coffey, Alison

AU - Jorgensen, Andrea

AU - Eleftherohorinou, Hariklia

AU - De Iorio, Maria

AU - Todaro, Marian

AU - De, Tisham

AU - Smith, David

AU - Smith, Philip E.

AU - Jackson, Margaret

AU - Cooper, Paul

AU - Kellett, Mark

AU - Howell, Stephen

AU - Newton, Mark

AU - Yerra, Raju

AU - Tan, Meng

AU - French, Chris

AU - Reuber, Markus

AU - Sills, Graeme E.

AU - Chadwick, David

AU - Pirmohamed, Munir

AU - Bentley, David

AU - Scheffer, Ingrid

AU - Berkovic, Samuel

AU - Balding, David

AU - Palotie, Aarno

AU - Marson, Anthony

AU - O'Brien, Terence J.

AU - Johnson, Michael R.

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