A genetic basis for multiple sclerosis severity: Red herring or real?

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Abstract

Multiple Sclerosis (MS) is an autoimmune degenerative disease of the central nervous system, characterized by multifocal demyelination and neurodegeneration. The genetic architecture of MS is complex, where genetic risk has been attributed to over 100 polymorphic loci each with small odds ratios. MS is a highly heterogeneous disease with numerous clinical and paraclinical endophenotypes. To-date, no genetic variant has been associated with clinical outcome, however, evidence exists that MS outcomes, like risk, are to an extent also controlled by genetic variation. Here we summarise the current evidence for genetic determination of disease outcomes and make recommendations for future research directions.

Original languageEnglish
Pages (from-to)357-365
Number of pages9
JournalMolecular and Cellular Probes
Volume30
Issue number6
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • Genetics
  • GWAS
  • Multiple sclerosis
  • Phenotype
  • Prognosis
  • SNP

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