A generalized transducing phage for the murine pathogen Citrobacter rodentium

Nicola K. Petty; Ana L. Toribio; David Goulding; Ian Foulds; Nicholas Thomson; Gordon Dougan; George P.C. Salmond

doi:10.1099/mic.0.2007/008888-0

A generalized transducing phage for the murine pathogen Citrobacter rodentium

Nicola K. Petty, Ana L. Toribio, David Goulding, Ian Foulds, Nicholas Thomson, Gordon Dougan, George P.C. Salmond

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

A virulent phage (φCR1) capable of generalized transduction in Citrobacter rodentium was isolated from the environment and characterized. C. rodentium is a natural pathogen of mice, causing transmissible murine colonic hyperplasia. Sequencing of its genome has recently been completed and will soon be fully annotated and published. C. rodentium is an important model organism for infections caused by the human pathogens enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC). φCR1 uses a lipopolysaccharide receptor, has a genome size of approximately 300 kb, and is able to transduce a variety of markers. φCR1 is the first reported transducing phage for C. rodentium and will be a useful tool for functional genomic analysis of this important natural murine pathogen.

Original language	English
Pages (from-to)	2984-2988
Number of pages	5
Journal	Microbiology
Volume	153
Issue number	9
DOIs	https://doi.org/10.1099/mic.0.2007/008888-0
Publication status	Published - 1 Sep 2007
Externally published	Yes

Access to Document

10.1099/mic.0.2007/008888-0

Cite this

@article{33e68400e4ef4086b770c9a7767efbc1,

title = "A generalized transducing phage for the murine pathogen Citrobacter rodentium",

abstract = "A virulent phage (φCR1) capable of generalized transduction in Citrobacter rodentium was isolated from the environment and characterized. C. rodentium is a natural pathogen of mice, causing transmissible murine colonic hyperplasia. Sequencing of its genome has recently been completed and will soon be fully annotated and published. C. rodentium is an important model organism for infections caused by the human pathogens enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC). φCR1 uses a lipopolysaccharide receptor, has a genome size of approximately 300 kb, and is able to transduce a variety of markers. φCR1 is the first reported transducing phage for C. rodentium and will be a useful tool for functional genomic analysis of this important natural murine pathogen.",

author = "Petty, {Nicola K.} and Toribio, {Ana L.} and David Goulding and Ian Foulds and Nicholas Thomson and Gordon Dougan and Salmond, {George P.C.}",

year = "2007",

month = sep,

day = "1",

doi = "10.1099/mic.0.2007/008888-0",

language = "English",

volume = "153",

pages = "2984--2988",

journal = "Microbiology-Sgm",

issn = "1350-0872",

number = "9",

}

TY - JOUR

T1 - A generalized transducing phage for the murine pathogen Citrobacter rodentium

AU - Petty, Nicola K.

AU - Toribio, Ana L.

AU - Goulding, David

AU - Foulds, Ian

AU - Thomson, Nicholas

AU - Dougan, Gordon

AU - Salmond, George P.C.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - A virulent phage (φCR1) capable of generalized transduction in Citrobacter rodentium was isolated from the environment and characterized. C. rodentium is a natural pathogen of mice, causing transmissible murine colonic hyperplasia. Sequencing of its genome has recently been completed and will soon be fully annotated and published. C. rodentium is an important model organism for infections caused by the human pathogens enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC). φCR1 uses a lipopolysaccharide receptor, has a genome size of approximately 300 kb, and is able to transduce a variety of markers. φCR1 is the first reported transducing phage for C. rodentium and will be a useful tool for functional genomic analysis of this important natural murine pathogen.

AB - A virulent phage (φCR1) capable of generalized transduction in Citrobacter rodentium was isolated from the environment and characterized. C. rodentium is a natural pathogen of mice, causing transmissible murine colonic hyperplasia. Sequencing of its genome has recently been completed and will soon be fully annotated and published. C. rodentium is an important model organism for infections caused by the human pathogens enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC). φCR1 uses a lipopolysaccharide receptor, has a genome size of approximately 300 kb, and is able to transduce a variety of markers. φCR1 is the first reported transducing phage for C. rodentium and will be a useful tool for functional genomic analysis of this important natural murine pathogen.

UR - http://www.scopus.com/inward/record.url?scp=34948814100&partnerID=8YFLogxK

U2 - 10.1099/mic.0.2007/008888-0

DO - 10.1099/mic.0.2007/008888-0

M3 - Article

C2 - 17768241

AN - SCOPUS:34948814100

VL - 153

SP - 2984

EP - 2988

JO - Microbiology-Sgm

JF - Microbiology-Sgm

SN - 1350-0872

IS - 9

ER -

A generalized transducing phage for the murine pathogen Citrobacter rodentium

Abstract

Access to Document

Other files and links

Cite this