A general model for binary cell fate decision gene circuits with degeneracy: indeterminacy and switch behavior in the absence of cooperativity

Mircea Andrecut, Julianne Halley, David Winkler, Sui Huang

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37 Citations (Scopus)

Abstract

The gene regulatory circuit motif in which two opposing fate-determining transcription factors inhibit each other but activate themselves has been used in mathematical models of binary cell fate decisions in multipotent stem or progenitor cells. This simple circuit can generate multistability and explains the symmetric a??poiseda?? precursor state in which both factors are present in the cell at equal amounts as well as the resolution of this indeterminate state as the cell commits to either cell fate characterized by an asymmetric expression pattern of the two factors. This establishes the two alternative stable attractors that represent the two fate options. It has been debated whether cooperativity of molecular interactions is necessary to produce such multistability.
Original languageEnglish
Article numbere19358
Number of pages9
JournalPLoS ONE
Volume6
Issue number5
DOIs
Publication statusPublished - 2011

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