A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue

Chintha Chamalie Handapangoda, Malin Premaratne, Saeid Nahavandi

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Abstract

Fluorescence has become a widely used technique for applications in noninvasive diagnostic tissue spectroscopy. The standard model used for characterizing fluorescence photon transport in biological tissue is based on the diffusion approximation. On the premise that the total energy of excitation and fluorescent photon flows must be conserved, we derive the widely used diffusion equations in fluorescence spectroscopy and show that there must be an additional term to account for the transport of fluorescent photons. The significance of this additional term in modeling fluorescence spectroscopy in biological tissue is assessed.
Original languageEnglish
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012)
Subtitle of host publicationSan Diego, California, USA, 28 August – 1 September 2012
EditorsGert Cauwenberghs, James D Weiland
Place of PublicationPiscataway, NJ
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages1494 - 1497
Number of pages4
ISBN (Print)9781424441198
DOIs
Publication statusPublished - 2012
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2012 - Hilton San Diego Bayfront, San Diego, United States of America
Duration: 28 Aug 20121 Sep 2012
Conference number: 34th
https://ieeexplore.ieee.org/xpl/conhome/6320834/proceeding (Proceedings)

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2012
Abbreviated titleEMBC 2012
CountryUnited States of America
CitySan Diego
Period28/08/121/09/12
Internet address

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