A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue

Chintha Chamalie Handapangoda; Malin Premaratne; Saeid Nahavandi

doi:10.1109/EMBC.2012.6346224

A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue

Chintha Chamalie Handapangoda, Malin Premaratne, Saeid Nahavandi

Electrical and Computer Systems Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

Abstract

Fluorescence has become a widely used technique for applications in noninvasive diagnostic tissue spectroscopy. The standard model used for characterizing fluorescence photon transport in biological tissue is based on the diffusion approximation. On the premise that the total energy of excitation and fluorescent photon flows must be conserved, we derive the widely used diffusion equations in fluorescence spectroscopy and show that there must be an additional term to account for the transport of fluorescent photons. The significance of this additional term in modeling fluorescence spectroscopy in biological tissue is assessed.

Original language	English
Title of host publication	2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012)
Subtitle of host publication	San Diego, California, USA, 28 August – 1 September 2012
Editors	Gert Cauwenberghs, James D Weiland
Place of Publication	Piscataway, NJ
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	1494 - 1497
Number of pages	4
ISBN (Print)	9781424441198
DOIs	https://doi.org/10.1109/EMBC.2012.6346224
Publication status	Published - 2012
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2012 - Hilton San Diego Bayfront, San Diego, United States of America Duration: 28 Aug 2012 → 1 Sept 2012 Conference number: 34th https://ieeexplore.ieee.org/xpl/conhome/6320834/proceeding (Proceedings)

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2012
Abbreviated title	EMBC 2012
Country/Territory	United States of America
City	San Diego
Period	28/08/12 → 1/09/12
Internet address	https://ieeexplore.ieee.org/xpl/conhome/6320834/proceeding (Proceedings)

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10.1109/EMBC.2012.6346224

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Handapangoda, C. C., Premaratne, M., & Nahavandi, S. (2012). A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue. In G. Cauwenberghs, & J. D. Weiland (Eds.), 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): San Diego, California, USA, 28 August – 1 September 2012 (pp. 1494 - 1497). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2012.6346224

Handapangoda, Chintha Chamalie ; Premaratne, Malin ; Nahavandi, Saeid. / A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): San Diego, California, USA, 28 August – 1 September 2012. editor / Gert Cauwenberghs ; James D Weiland. Piscataway, NJ : IEEE, Institute of Electrical and Electronics Engineers, 2012. pp. 1494 - 1497

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abstract = "Fluorescence has become a widely used technique for applications in noninvasive diagnostic tissue spectroscopy. The standard model used for characterizing fluorescence photon transport in biological tissue is based on the diffusion approximation. On the premise that the total energy of excitation and fluorescent photon flows must be conserved, we derive the widely used diffusion equations in fluorescence spectroscopy and show that there must be an additional term to account for the transport of fluorescent photons. The significance of this additional term in modeling fluorescence spectroscopy in biological tissue is assessed.",

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doi = "10.1109/EMBC.2012.6346224",

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publisher = "IEEE, Institute of Electrical and Electronics Engineers",

address = "United States of America",

note = "International Conference of the IEEE Engineering in Medicine and Biology Society 2012, EMBC 2012 ; Conference date: 28-08-2012 Through 01-09-2012",

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Handapangoda, CC, Premaratne, M & Nahavandi, S 2012, A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue. in G Cauwenberghs & JD Weiland (eds), 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): San Diego, California, USA, 28 August – 1 September 2012. IEEE, Institute of Electrical and Electronics Engineers, Piscataway, NJ, pp. 1494 - 1497, International Conference of the IEEE Engineering in Medicine and Biology Society 2012, San Diego, California, United States of America, 28/08/12. https://doi.org/10.1109/EMBC.2012.6346224

A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue. / Handapangoda, Chintha Chamalie; Premaratne, Malin; Nahavandi, Saeid.
2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): San Diego, California, USA, 28 August – 1 September 2012. ed. / Gert Cauwenberghs; James D Weiland. Piscataway, NJ: IEEE, Institute of Electrical and Electronics Engineers, 2012. p. 1494 - 1497.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AB - Fluorescence has become a widely used technique for applications in noninvasive diagnostic tissue spectroscopy. The standard model used for characterizing fluorescence photon transport in biological tissue is based on the diffusion approximation. On the premise that the total energy of excitation and fluorescent photon flows must be conserved, we derive the widely used diffusion equations in fluorescence spectroscopy and show that there must be an additional term to account for the transport of fluorescent photons. The significance of this additional term in modeling fluorescence spectroscopy in biological tissue is assessed.

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Handapangoda CC, Premaratne M, Nahavandi S. A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue. In Cauwenberghs G, Weiland JD, editors, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): San Diego, California, USA, 28 August – 1 September 2012. Piscataway, NJ: IEEE, Institute of Electrical and Electronics Engineers. 2012. p. 1494 - 1497 doi: 10.1109/EMBC.2012.6346224

A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue

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