Projects per year
Abstract
The development of an efficient, high yielding six-step convergent synthesis of the semisynthetic alkaloid (-)-perhydrohistrionicotoxin is described. The key transformations include the cross metathesis of a Brønsted-acid masked primary homoallylic amine with a vinyl cyclohexenone and a regioselective palladium catalyzed hydrogenation. This sequence generated the advanced Winterfeldt spirocyclic precursor in 47% overall yield, with a longest linear sequence of five steps.
Original language | English |
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Pages (from-to) | 8725-8732 |
Number of pages | 8 |
Journal | The Journal of Organic Chemistry |
Volume | 82 |
Issue number | 16 |
DOIs | |
Publication status | Published - 18 Aug 2017 |
Projects
- 1 Finished
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New metal catalysed tandem routes to nitrogen containing compounds
Robinson, A. (Primary Chief Investigator (PCI)) & Jackson, R. (Chief Investigator (CI))
Australian Research Council (ARC)
3/01/12 → 6/01/15
Project: Research