A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

Cassandra L. Fleming, Trent Ashton, Cameron Nowell, Mark Devlin, Anthony Natoli, Jeannette Schreuders, Frederick M. Pfeffer

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19 Citations (Scopus)

Abstract

Fluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify 'profluorogenic' substrates for intracellular studies.

Original languageEnglish
Pages (from-to)7827-7830
Number of pages4
JournalChemical Communications
Volume51
Issue number37
DOIs
Publication statusPublished - 7 May 2015

Cite this

Fleming, C. L., Ashton, T., Nowell, C., Devlin, M., Natoli, A., Schreuders, J., & Pfeffer, F. M. (2015). A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging. Chemical Communications, 51(37), 7827-7830. https://doi.org/10.1039/c5cc02059j