A feasibility study of X-ray phase-contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron

Yakov Nesterets, Timur Eugenievich Gureyev, Sheridan C Mayo, Andrew W Stevenson, Darren Thompson, Jeremy Michael Cooney Brown, Marcus John Kitchen, Konstantin Mikhailovitch Pavlov, Darren Lockie, Francesco Brun, Giuliana Tromba

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Abstract

Results are presented of a recent experiment at the Imaging and Medical beamline of the Australian Synchrotron intended to contribute to the implementation of low-dose high-sensitivity three-dimensional mammographic phase-contrast imaging, initially at synchrotrons and subsequently in hospitals and medical imaging clinics. The effect of such imaging parameters as X-ray energy, source size, detector resolution, sample-to-detector distance, scanning and data processing strategies in the case of propagation-based phase-contrast computed tomography (CT) have been tested, quantified, evaluated and optimized using a plastic phantom simulating relevant breast-tissue characteristics. Analysis of the data collected using a Hamamatsu CMOS Flat Panel Sensor, with a pixel size of 100 µm, revealed the presence of propagation-based phase contrast and demonstrated significant improvement of the quality of phase-contrast CT imaging compared with conventional (absorption-based) CT, at medically acceptable radiation doses.
Original languageEnglish
Pages (from-to)1509-1523
Number of pages15
JournalJournal of Synchrotron Radiation
Volume22
Issue number6
DOIs
Publication statusPublished - 2015

Keywords

  • X-rays
  • phase contrast
  • computed tomography
  • mammography

Cite this

Nesterets, Y., Gureyev, T. E., Mayo, S. C., Stevenson, A. W., Thompson, D., Brown, J. M. C., Kitchen, M. J., Pavlov, K. M., Lockie, D., Brun, F., & Tromba, G. (2015). A feasibility study of X-ray phase-contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron. Journal of Synchrotron Radiation, 22(6), 1509-1523. https://doi.org/10.1107/S160057751501766X