A Facile Ion-Doping Strategy to Regulate Tumor Microenvironments for Enhanced Multimodal Tumor Theranostics

Jing Bai, Xiaodan Jia, Wenyao Zhen, Wenlong Cheng, Xiue Jiang

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

Abstract

Integration of multiple therapeutic/diagnostic modalities into a single system holds great promise to improve theranostic efficiency for tumors, but still remains a technical challenge. Herein, we report a new multimodal theranostic nanoconstruct based on Fe-doped polydiaminopyridine nanofusiforms, built easily and on a large scale, which can dual-regulate intracellular oxygen and glutathione levels, transport iron ions, and simultaneously be used for thermal imaging and magnetic resonance imaging. Co-loading of dihydroartemisinin and methylene blue generates a superior multifunctional theranostic agent with enhanced photochemotherapy efficiency and biodegradability, leading to almost complete destruction of tumors with near-infrared light irradiation. This represents an attractive route to develop multimodal anticancer theranostics.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalJournal of the American Chemical Society
Volume140
Issue number1
DOIs
Publication statusPublished - 10 Jan 2018

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