TY - JOUR
T1 - A Facile Ion-Doping Strategy to Regulate Tumor Microenvironments for Enhanced Multimodal Tumor Theranostics
AU - Bai, Jing
AU - Jia, Xiaodan
AU - Zhen, Wenyao
AU - Cheng, Wenlong
AU - Jiang, Xiue
PY - 2018/1/10
Y1 - 2018/1/10
N2 - Integration of multiple therapeutic/diagnostic modalities into a single system holds great promise to improve theranostic efficiency for tumors, but still remains a technical challenge. Herein, we report a new multimodal theranostic nanoconstruct based on Fe-doped polydiaminopyridine nanofusiforms, built easily and on a large scale, which can dual-regulate intracellular oxygen and glutathione levels, transport iron ions, and simultaneously be used for thermal imaging and magnetic resonance imaging. Co-loading of dihydroartemisinin and methylene blue generates a superior multifunctional theranostic agent with enhanced photochemotherapy efficiency and biodegradability, leading to almost complete destruction of tumors with near-infrared light irradiation. This represents an attractive route to develop multimodal anticancer theranostics.
AB - Integration of multiple therapeutic/diagnostic modalities into a single system holds great promise to improve theranostic efficiency for tumors, but still remains a technical challenge. Herein, we report a new multimodal theranostic nanoconstruct based on Fe-doped polydiaminopyridine nanofusiforms, built easily and on a large scale, which can dual-regulate intracellular oxygen and glutathione levels, transport iron ions, and simultaneously be used for thermal imaging and magnetic resonance imaging. Co-loading of dihydroartemisinin and methylene blue generates a superior multifunctional theranostic agent with enhanced photochemotherapy efficiency and biodegradability, leading to almost complete destruction of tumors with near-infrared light irradiation. This represents an attractive route to develop multimodal anticancer theranostics.
UR - http://www.scopus.com/inward/record.url?scp=85040330432&partnerID=8YFLogxK
U2 - 10.1021/jacs.7b11114
DO - 10.1021/jacs.7b11114
M3 - Article
C2 - 29268612
AN - SCOPUS:85040330432
SN - 0002-7863
VL - 140
SP - 106
EP - 109
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 1
ER -