A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility

S. Srivannaboon; G. I. Dhall; D. M. De Krester; T. B. Hargreave; F. H. Comhaire; R. S. Padron; J. Mas; V. Hingorani; C. Miranda; I. D. Cooke; J. Vernon-Parry; K. Hagenfeldt; M. Sas; B. A. Resch; A. Ladjimi; R. Bourkhris; T. M M Farley; P. J. Rowe; C. Hazelden

A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility

S. Srivannaboon, G. I. Dhall, D. M. De Krester, T. B. Hargreave, F. H. Comhaire, R. S. Padron, J. Mas, V. Hingorani, C. Miranda, I. D. Cooke, J. Vernon-Parry, K. Hagenfeldt, M. Sas, B. A. Resch, A. Ladjimi, R. Bourkhris, T. M M Farley, P. J. Rowe, C. Hazelden

Research output: Contribution to journal › Article › Research › peer-review

Abstract

A multicentre, randomized double-blind study was performed to assess the effect on male fertility of treatment with low dose clomiphene citrate. One hundred and ninety couples were included in whom the male diagnosis was idiopathic impairment of semen quality. and the female partner had no demonstrable abnormality or was under successful treatment for a minor endocrine problem. A total of 1308 couple-months were studied. Men received either 25 mg clomiphene citrate daily or placebo for 6 months. The cumulative life-table pregnancy rates at 8 months were 11.7% and 8.1% in the placebo and clomiphene groups respectively. There were no significant differences between the changes in semen quality during intake of either clomiphene or placebo. This study provides no evidence for the efficacy of clomiphene citrate for the treatment of idiopathic male infertility.

Original language	English
Pages (from-to)	299-307
Number of pages	9
Journal	International Journal of Andrology
Volume	15
Issue number	4
Publication status	Published - 1992
Externally published	Yes

Keywords

Anti-oestrogen
Clomiphene
Male infertility
Ologozoospermia

Cite this

Srivannaboon, S., Dhall, G. I., De Krester, D. M., Hargreave, T. B., Comhaire, F. H., Padron, R. S., Mas, J., Hingorani, V., Miranda, C., Cooke, I. D., Vernon-Parry, J., Hagenfeldt, K., Sas, M., Resch, B. A., Ladjimi, A., Bourkhris, R., Farley, T. M. M., Rowe, P. J., & Hazelden, C. (1992). A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility. International Journal of Andrology, 15(4), 299-307.

@article{0e81d324b798475cae5d5954bcbe3bae,

title = "A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility",

abstract = "A multicentre, randomized double-blind study was performed to assess the effect on male fertility of treatment with low dose clomiphene citrate. One hundred and ninety couples were included in whom the male diagnosis was idiopathic impairment of semen quality. and the female partner had no demonstrable abnormality or was under successful treatment for a minor endocrine problem. A total of 1308 couple-months were studied. Men received either 25 mg clomiphene citrate daily or placebo for 6 months. The cumulative life-table pregnancy rates at 8 months were 11.7% and 8.1% in the placebo and clomiphene groups respectively. There were no significant differences between the changes in semen quality during intake of either clomiphene or placebo. This study provides no evidence for the efficacy of clomiphene citrate for the treatment of idiopathic male infertility.",

keywords = "Anti-oestrogen, Clomiphene, Male infertility, Ologozoospermia",

author = "S. Srivannaboon and Dhall, {G. I.} and {De Krester}, {D. M.} and Hargreave, {T. B.} and Comhaire, {F. H.} and Padron, {R. S.} and J. Mas and V. Hingorani and C. Miranda and Cooke, {I. D.} and J. Vernon-Parry and K. Hagenfeldt and M. Sas and Resch, {B. A.} and A. Ladjimi and R. Bourkhris and Farley, {T. M M} and Rowe, {P. J.} and C. Hazelden",

year = "1992",

language = "English",

volume = "15",

pages = "299--307",

journal = "International Journal of Andrology",

issn = "0105-6263",

publisher = "Wiley-Blackwell",

number = "4",

}

Srivannaboon, S, Dhall, GI, De Krester, DM, Hargreave, TB, Comhaire, FH, Padron, RS, Mas, J, Hingorani, V, Miranda, C, Cooke, ID, Vernon-Parry, J, Hagenfeldt, K, Sas, M, Resch, BA, Ladjimi, A, Bourkhris, R, Farley, TMM, Rowe, PJ & Hazelden, C 1992, 'A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility', International Journal of Andrology, vol. 15, no. 4, pp. 299-307.

TY - JOUR

T1 - A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility

AU - Srivannaboon, S.

AU - Dhall, G. I.

AU - De Krester, D. M.

AU - Hargreave, T. B.

AU - Comhaire, F. H.

AU - Padron, R. S.

AU - Mas, J.

AU - Hingorani, V.

AU - Miranda, C.

AU - Cooke, I. D.

AU - Vernon-Parry, J.

AU - Hagenfeldt, K.

AU - Sas, M.

AU - Resch, B. A.

AU - Ladjimi, A.

AU - Bourkhris, R.

AU - Farley, T. M M

AU - Rowe, P. J.

AU - Hazelden, C.

PY - 1992

Y1 - 1992

N2 - A multicentre, randomized double-blind study was performed to assess the effect on male fertility of treatment with low dose clomiphene citrate. One hundred and ninety couples were included in whom the male diagnosis was idiopathic impairment of semen quality. and the female partner had no demonstrable abnormality or was under successful treatment for a minor endocrine problem. A total of 1308 couple-months were studied. Men received either 25 mg clomiphene citrate daily or placebo for 6 months. The cumulative life-table pregnancy rates at 8 months were 11.7% and 8.1% in the placebo and clomiphene groups respectively. There were no significant differences between the changes in semen quality during intake of either clomiphene or placebo. This study provides no evidence for the efficacy of clomiphene citrate for the treatment of idiopathic male infertility.

AB - A multicentre, randomized double-blind study was performed to assess the effect on male fertility of treatment with low dose clomiphene citrate. One hundred and ninety couples were included in whom the male diagnosis was idiopathic impairment of semen quality. and the female partner had no demonstrable abnormality or was under successful treatment for a minor endocrine problem. A total of 1308 couple-months were studied. Men received either 25 mg clomiphene citrate daily or placebo for 6 months. The cumulative life-table pregnancy rates at 8 months were 11.7% and 8.1% in the placebo and clomiphene groups respectively. There were no significant differences between the changes in semen quality during intake of either clomiphene or placebo. This study provides no evidence for the efficacy of clomiphene citrate for the treatment of idiopathic male infertility.

KW - Anti-oestrogen

KW - Clomiphene

KW - Male infertility

KW - Ologozoospermia

UR - http://www.scopus.com/inward/record.url?scp=0026768050&partnerID=8YFLogxK

M3 - Article

C2 - 1516979

SN - 0105-6263

VL - 15

SP - 299

EP - 307

JO - International Journal of Andrology

JF - International Journal of Andrology

IS - 4

ER -

A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility

Abstract

Keywords

Other files and links

Cite this