A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression

Paul Bernard Fitzgerald, Kate Elizabeth Hoy, Sally Elizabeth Herring, Susan Ann McQueen, Amy Peachey, Rebecca Anne Segrave, Jerome Joseph Maller, Phillip Jeremy Hall, Zafiris Jeff Daskalakis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rtms) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in efficacy of sequential bilateral rtms compared to standard high-frequency left sided rtms. Sixty seven patients with treatment resistant depression were included in a randomised double-blind sham controlled trial of sequential bilateral rTMS compared to standard high-frequency left sided rtms and sham rTMS over a three-week period. The study also included a further three week comparison of the two active treatment conditions. The primary outcome variable was scores on the 17-item Hamilton Depression Rating Scale (hamd). In the three-week double-blind phase of the trial there was a greater antidepressant response to unilateral left sided rtms compared with sham or bilateral rtms. Across the full six weeks of active rtms, there was also a consistent pattern of improved response in unilateral left compared to bilateral treatment. Response rates were low in both active groups. This study does not support the hypothesis that sequential bilateral rtms is more effective than unilateral high-frequency left-sided rtms.
Original languageEnglish
Pages (from-to)193 - 198
Number of pages6
JournalJournal of Affective Disorders
Volume139
Issue number2
DOIs
Publication statusPublished - 2012

Cite this

@article{17c106775c8a476799bb3ee38b325c47,
title = "A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression",
abstract = "A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rtms) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in efficacy of sequential bilateral rtms compared to standard high-frequency left sided rtms. Sixty seven patients with treatment resistant depression were included in a randomised double-blind sham controlled trial of sequential bilateral rTMS compared to standard high-frequency left sided rtms and sham rTMS over a three-week period. The study also included a further three week comparison of the two active treatment conditions. The primary outcome variable was scores on the 17-item Hamilton Depression Rating Scale (hamd). In the three-week double-blind phase of the trial there was a greater antidepressant response to unilateral left sided rtms compared with sham or bilateral rtms. Across the full six weeks of active rtms, there was also a consistent pattern of improved response in unilateral left compared to bilateral treatment. Response rates were low in both active groups. This study does not support the hypothesis that sequential bilateral rtms is more effective than unilateral high-frequency left-sided rtms.",
author = "Fitzgerald, {Paul Bernard} and Hoy, {Kate Elizabeth} and Herring, {Sally Elizabeth} and McQueen, {Susan Ann} and Amy Peachey and Segrave, {Rebecca Anne} and Maller, {Jerome Joseph} and Hall, {Phillip Jeremy} and Daskalakis, {Zafiris Jeff}",
year = "2012",
doi = "10.1016/j.jad.2012.02.017",
language = "English",
volume = "139",
pages = "193 -- 198",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "2",

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A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression. / Fitzgerald, Paul Bernard; Hoy, Kate Elizabeth; Herring, Sally Elizabeth; McQueen, Susan Ann; Peachey, Amy; Segrave, Rebecca Anne; Maller, Jerome Joseph; Hall, Phillip Jeremy; Daskalakis, Zafiris Jeff.

In: Journal of Affective Disorders, Vol. 139, No. 2, 2012, p. 193 - 198.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression

AU - Fitzgerald, Paul Bernard

AU - Hoy, Kate Elizabeth

AU - Herring, Sally Elizabeth

AU - McQueen, Susan Ann

AU - Peachey, Amy

AU - Segrave, Rebecca Anne

AU - Maller, Jerome Joseph

AU - Hall, Phillip Jeremy

AU - Daskalakis, Zafiris Jeff

PY - 2012

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N2 - A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rtms) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in efficacy of sequential bilateral rtms compared to standard high-frequency left sided rtms. Sixty seven patients with treatment resistant depression were included in a randomised double-blind sham controlled trial of sequential bilateral rTMS compared to standard high-frequency left sided rtms and sham rTMS over a three-week period. The study also included a further three week comparison of the two active treatment conditions. The primary outcome variable was scores on the 17-item Hamilton Depression Rating Scale (hamd). In the three-week double-blind phase of the trial there was a greater antidepressant response to unilateral left sided rtms compared with sham or bilateral rtms. Across the full six weeks of active rtms, there was also a consistent pattern of improved response in unilateral left compared to bilateral treatment. Response rates were low in both active groups. This study does not support the hypothesis that sequential bilateral rtms is more effective than unilateral high-frequency left-sided rtms.

AB - A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rtms) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in efficacy of sequential bilateral rtms compared to standard high-frequency left sided rtms. Sixty seven patients with treatment resistant depression were included in a randomised double-blind sham controlled trial of sequential bilateral rTMS compared to standard high-frequency left sided rtms and sham rTMS over a three-week period. The study also included a further three week comparison of the two active treatment conditions. The primary outcome variable was scores on the 17-item Hamilton Depression Rating Scale (hamd). In the three-week double-blind phase of the trial there was a greater antidepressant response to unilateral left sided rtms compared with sham or bilateral rtms. Across the full six weeks of active rtms, there was also a consistent pattern of improved response in unilateral left compared to bilateral treatment. Response rates were low in both active groups. This study does not support the hypothesis that sequential bilateral rtms is more effective than unilateral high-frequency left-sided rtms.

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