A dose-specific meta-analysis of lipid changes in randomized controlled trials of atorvastatin and simvastatin

Sophie Louise Rogers, Dianna Josephine Magliano, Dane B Levison, Kate Webb, Philippa J Clarke, Mendel P Grobler, Danny Yearn Hian Liew

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33 Citations (Scopus)


BACKGROUND: The available statins exhibit differences in the potency with which they alter serum lipid levels. OBJECTIVE: Meta-analyses were conducted to assess the relative potency of atorvastatin and simvastatin (the 2 most commonly prescribed statins) across all possible dose combinations in terms of changes in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C). METHODS: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, National Health Service (NHS) Centre for Reviews and Dissemination database, NHS Economic Evaluation Database, and Database of Abstracts of Reviews of Effects were searched for randomized, head-to-head trials of atorvastatin and simvastatin in patients aged >or=18 years with elevated levels of serum TC and LDL-C. Reference lists of the identified articles, letters, and editorials also were reviewed. The manufacturers of atorvastatin and simvastatin products were contacted for relevant unpublished data. All studies were reviewed and rated for quality by 2 independent reviewers. The maximum quality score was 4 points; trials with a score of
Original languageEnglish
Pages (from-to)242 - 252
Number of pages11
JournalClinical Therapeutics
Issue number2
Publication statusPublished - 2007

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