A donor PaO2/FiO2 < 300 mm Hg does not determine graft function or survival after lung transplantation

Helen Whitford, Christina E. Kure, Aimee Henriksen, Jamie Hobson, Greg I. Snell, Bronwyn J. Levvey, Silvana F. Marasco, Julian H. Gooi, Adam Zimmet, Justin Negri, Adrian Pick, Mark Buckland, Trevor Williams, Glenn Westall, Miranda A. Paraskeva, Catherine Martin, David C. McGiffin

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Abstract

BACKGROUND: A donor arterial PO2/FiO2 (P/F ratio) of less than the 300 threshold would frequently result in either exclusion of the donor or placement of the lungs on ex vivo lung perfusion (EVLP). The aim was to investigate the veracity of the P/F ratio threshold of 300 for donor lung acceptability. METHODS: In 93 brain dead lung donors, arterial blood gases were drawn in the intensive care unit (ICU) just before procurement and each of the 4 donor pulmonary veins in the operating room (OR). No donor lungs were rejected for transplantation based on the last ICU or OR P/F ratio, and EVLP was not used. The recipients were followed up 6 and 12 months following transplantation. RESULTS: There were 93 recipients of bilateral lung transplantation. An arterial P/F ratio of < 300 was largely driven by a low P/F ratio in the lower lobes. There were no differences between the recipients receiving donor lungs where the ICU P/F ratio was < 300 compared with ≥ 300 in the time to extubation, grade of primary graft dysfunction, pulmonary function at 6 and 12 months, and 12-month survival. CONCLUSIONS: From this study:(1) If a donor P/F threshold of 300 was adhered to, 36% would have been rejected, and (2) The donor P/F ratio threshold of 300 is excessively conservative and results in the wastage of donor lungs and the application of unnecessary EVLP.

Original languageEnglish
Pages (from-to)53-61
Number of pages9
JournalJournal of Heart and Lung Transplantation
Volume39
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • lung transplantation
  • Organ donor
  • organ ultilization
  • PaO, P/F ratio

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