@article{6ad084a5fe784e1bba89fc82d1d42907,
title = "A Diazo-Hooker Reaction, Inspired by the Biosynthesis of Azamerone",
abstract = "Motivated by the biosynthesis of azamerone, we report the first example of a diazo-Hooker reaction, which involves the formation of a phthalazine ring system by the oxidative rearrangement of a diazoketone. Computational studies indicate that the diazo-Hooker reaction proceeds via an 8π-electrocyclization followed by ring contraction and aromatization. The biosynthetic origin of the diazoketone functional group was also chemically mimicked using a related natural product, naphterpin, as a model system.",
author = "Oussama Yahiaoui and Murray, {Lauren A.M.} and Fengyue Zhao and Moore, {Bradley S.} and Houk, {Kendall N.} and Fang Liu and George, {Jonathan H.}",
note = "Funding Information: This work was supported by the Australian Research Council (Discovery Project, DP200102964 to J.H.G.), the Natural Science Foundation of Jiangsu Province, China (BK20190505 to F.L.), the U.S. National Institutes of Health (R01-AI047818 to B.S.M.), and the U.S. National Science Foundation (CHE-1764328 to K.N.H.). Publisher Copyright: {\textcopyright} 2022 American Chemical Society",
year = "2022",
month = jan,
day = "21",
doi = "10.1021/acs.orglett.1c03810",
language = "English",
volume = "24",
pages = "490--495",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "2",
}