A deep learning–based automatic system for intracranial aneurysms diagnosis on three-dimensional digital subtraction angiographic images

Chubin Ou, Yi Qian, Winston Chong, Xiaoxi Hou, Mingzi Zhang, Xin Zhang, Weixin Si, Chuan-Zhi Duan

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Background: Intracranial aneurysms (IAs) are a life-threatening disease. Their rupture can lead to hemorrhagic stroke. Most studies applying deep learning for the detection of aneurysms are based on angiographic images. However, critical diagnostic information such as morphology and aneurysm location are not captured by deep learning algorithms and still require manual assessments. Purpose: Digital subtraction angiography (DSA) is the gold standard for aneurysm diagnosis. To facilitate the fully automatic diagnosis of aneurysms, we proposed a comprehensive system for the detection, morphology measurement, and location classification of aneurysms on three-dimensional DSA images, allowing automatic diagnosis without further human input. Methods: The system comprised three neural networks: a network for aneurysm detection, a network for morphology measurement, and a network for aneurysm location identification. A cross-scale dual-path transformer module was proposed to effectively fuse local and global information to capture aneurysms of varying sizes. A multitask learning approach was also proposed to allow an accurate localization of aneurysm neck for morphology measurement. Results: The cross-scale dual-path transformer module was shown to outperform other state-of-the-art network architectures, improving segmentation, and classification accuracy. The detection network in our system achieved an F2 score of 0.946 (recall 93%, precision 100%), better than the winning team in the Cerebral Aneurysm Detection and Analysis challenge. The measurement network achieved a relative error of less than 10% for morphology measurement, at the same level as human operators. Perfect accuracy (100%) was achieved on aneurysm location classification. Conclusions: We have demonstrated that a comprehensive system can automatically detect, measure morphology and report the aneurysm location of aneurysms without human intervention. This can be a potential tool for the diagnosis of IAs, improving radiologists’ performance and reducing their workload.

Original languageEnglish
Pages (from-to)7038-7053
Number of pages16
JournalMedical Physics
Issue number11
Publication statusPublished - Nov 2022
Externally publishedYes


  • computer-aided diagnosis
  • deep learning
  • digital subtraction angiography
  • intracranial aneurysm
  • multitask learning
  • stroke
  • transformer

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