A Decade of the Protein Corona

Pu Chun Ke, Sijie Lin, Wolfgang J. Parak, Thomas P. Davis, Frank Caruso

Research output: Contribution to journalReview ArticleResearchpeer-review

170 Citations (Scopus)


In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future science and engineering at the bio-nano interface. Specifically, we focus on the physical origins and time evolution of the protein corona, differences in the nanoparticle-protein entity in in vitro and in vivo environments, the role of stealth polymers to minimize the formation of the protein corona, relevant computational and theoretical developments, and the "biocorona", a concept extrapolated from the field of nanomedicine. We conclude the Perspective by outlining future directions and opportunities concerning the protein corona in the coming decade.

Original languageEnglish
Pages (from-to)11773-11776
Number of pages4
JournalACS Nano
Issue number12
Publication statusPublished - 26 Dec 2017

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