A cost-minimisation analysis comparing different antibiotic regimens used in treating all-cause bacterial pneumonia in Hong Kong

Kenneth K.C. Lee, Matthew H.S. Wan, Barry S.K. Fan, Michelle W.Y. Chau, Vivian W.Y. Lee

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Background: To find out the antibiotic treatment regimens with the lowest cost for all-cause bacterial pneumonia, a study to compare the costs of different antibiotic regimens in the treatment of patients diagnosed with all-cause bacterial pneumonia who required hospitalisation was carried out. Methodology: This was a multicentre, retrospective study of patient medical records. The primary aim was to examine whether the initial choice of antibiotic had affected the total cost of treatment, while the secondary aim was to find out whether the initial choice of antibiotic had affected the initial treatment failure rates and death rates. A cost-minimisation analysis (CMA) from a public hospital perspective was employed. Results: A total of 333 patient medical case notes were reviewed. The most commonly prescribed antibiotic regimen was amoxycillin-clavulanate (AC) followed by amoxycillin-clavulanate plus macrolide (ACM) and quinolone (Q). In the study population, no statistical significance could be detected between the mean cost of the three regimens. In the subgroup analysis of patients with a history of chronic obstructive pulmonary disease (COPD) and patients with a history of smoking, the Q regimen appeared to be the least expensive. Conclusion: In the study population, no significant difference could be identified between the mean cost of the three antibiotic regimens. In a special populations such as patients with a history of COPD and patients with a history of smoking, the Q regimen appeared to be superior. Further studies in these areas are needed.

Original languageEnglish
Pages (from-to)46-55
Number of pages10
JournalJournal of Medical Economics
Volume12
Issue number1
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • All-cause bacterial pneumonia
  • Antibiotics
  • Cost-minimisation analysis

Cite this