TY - JOUR
T1 - A core outcome set for future endometriosis research
T2 - an international consensus development study
AU - Duffy, J. M.N.
AU - Hirsch, M.
AU - Vercoe, M.
AU - Abbott, J.
AU - Barker, C.
AU - Collura, B.
AU - Drake, R.
AU - Evers, J. L.H.
AU - Hickey, M.
AU - Horne, A. W.
AU - Hull, M. L.
AU - Kolekar, S.
AU - Lensen, S.
AU - Johnson, N. P.
AU - Mahajan, V.
AU - Mol, B. W.
AU - Otter, A. S.
AU - Puscasiu, L.
AU - Rodriguez, M. B.
AU - Rombauts, L.
AU - Vail, A.
AU - Wang, R.
AU - Farquhar, C. M.
AU - Daniels, Jane P.
AU - Lim, Arianne C.
AU - Edmonds, Katie
AU - MacLean, Claire E.
AU - Appleton, Amy C.
AU - Skelton, Sarah
AU - Byrne, Dominic L.
AU - White, Rebecca K.
AU - Sardo, Margarida
AU - Fowles, Rebecca C.
AU - Ata, Baris
AU - Richatd, Sarah A.
AU - Puig Ybanez, Casandra C.
AU - Peterson, Matthew C.
AU - Elms, Jasmin L.
AU - Parks, Ann
AU - De Bie Rocks, Bianca L.F.
AU - Roe, Jodie C.
AU - Doran, Ruby
AU - Ceccaroni, Marcello
AU - Ferreira, Ceu A.
AU - Dias, Sofia
AU - Pinnington, Tracey
AU - Laupa-Santiago, Paula
AU - Turner, Marie C.
AU - Schreurs, Anneke M.F.
AU - Baggot, Eleanor
AU - Socolov, Razvan V.
AU - Yossry, Menem
AU - Hodges, Tania M.
AU - Barbossa, Marina W.P.
AU - Lytwyn, Tracy L.
AU - Egan-Reid, Sophia E.L.
AU - Devlin, Susanna C.L.
AU - Crees, Kira S.
AU - Baldwin, Bethany C.
AU - Scott, James R.
AU - Gravolin, Amy K.
AU - Chapman, Errin F.
AU - Bartley, Stephanie N.
AU - Hamilton, Alicia J.
AU - Thorpe, Kirstie J.
AU - Carmody, Denise M.
AU - Eyeson, Joanna
AU - Davis, Madeleine D.
AU - Henry, Jo
AU - Armour, Mike
AU - Cummings, Presley Y.F.V.
AU - Cook, Lisa A.
AU - endo:outcomes – an International Collaboration Harmonising Outcomes and Outcome Measures for Endometriosis Research
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Objective: To develop a core outcome set for endometriosis. Design: Consensus development study. Setting: International. Population: One hundred and sixteen healthcare professionals, 31 researchers, and 206 patient representatives. Methods: Modified Delphi method and modified nominal group technique. Results: The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life. In addition, eight core outcomes for trials evaluating potential treatments for infertility associated with endometriosis were identified: viable intrauterine pregnancy confirmed by ultrasound; pregnancy loss, including ectopic pregnancy, miscarriage, stillbirth, and termination of pregnancy; live birth; time to pregnancy leading to live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital abnormalities. Two core outcomes applicable to all trials were also identified: adverse events and patient satisfaction with treatment. Conclusions: Using robust consensus science methods, healthcare professionals, researchers, and women with endometriosis have developed a core outcome set to standardise outcome selection, collection, and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. Tweetable abstract: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy.
AB - Objective: To develop a core outcome set for endometriosis. Design: Consensus development study. Setting: International. Population: One hundred and sixteen healthcare professionals, 31 researchers, and 206 patient representatives. Methods: Modified Delphi method and modified nominal group technique. Results: The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life. In addition, eight core outcomes for trials evaluating potential treatments for infertility associated with endometriosis were identified: viable intrauterine pregnancy confirmed by ultrasound; pregnancy loss, including ectopic pregnancy, miscarriage, stillbirth, and termination of pregnancy; live birth; time to pregnancy leading to live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital abnormalities. Two core outcomes applicable to all trials were also identified: adverse events and patient satisfaction with treatment. Conclusions: Using robust consensus science methods, healthcare professionals, researchers, and women with endometriosis have developed a core outcome set to standardise outcome selection, collection, and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. Tweetable abstract: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy.
KW - Consensus development study
KW - core outcome set
KW - endometriosis
KW - modified Delphi method
KW - modified nominal group technique
UR - http://www.scopus.com/inward/record.url?scp=85082518520&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.16157
DO - 10.1111/1471-0528.16157
M3 - Article
AN - SCOPUS:85082518520
VL - 127
SP - 967
EP - 974
JO - BJOG: an International Journal of Obstetrics and Gynaecology
JF - BJOG: an International Journal of Obstetrics and Gynaecology
SN - 1470-0328
IS - 8
ER -