A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques

Sinchun Lim, Brett M. Paterson, Michelle T. Fodero-Tavoletti, Graeme J. O'Keefe, Roberto Cappai, Kevin J. Barnham, Victor L. Villemagne, Paul S. Donnelly

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51 Citations (Scopus)

Abstract

A bis(thiosemicarbazonato)copper(ii) complex with an appended stilbene functional group binds to amyloid-β plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.

Original languageEnglish
Pages (from-to)5437-5439
Number of pages3
JournalChemical Communications
Volume46
Issue number30
DOIs
Publication statusPublished - 14 Aug 2010
Externally publishedYes

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