TY - JOUR
T1 - A contribution of mouse dendritic cell-derived IL-2 for NK cell activation
AU - Granucci, Francesca
AU - Zanoni, Ivan
AU - Pavelka, Norman
AU - Van Dommelen, Serani L.H.
AU - Andoniou, Christopher E.
AU - Belardelli, Filippo
AU - Degli Esposti, Mariapia A.
AU - Ricciardi-Castagnoli, Paola
PY - 2004/8/2
Y1 - 2004/8/2
N2 - Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required for optimal priming of NK cells. Type I interferons (IFNs) promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and in vivo for the efficient production of IFNγ, which has an important antimetastatic and antibacterial function. These findings provide new information about the mechanisms that mediate DC-NK cell interactions and define a novel and fundamental role for IL-2 in innate immunity.
AB - Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required for optimal priming of NK cells. Type I interferons (IFNs) promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and in vivo for the efficient production of IFNγ, which has an important antimetastatic and antibacterial function. These findings provide new information about the mechanisms that mediate DC-NK cell interactions and define a novel and fundamental role for IL-2 in innate immunity.
KW - Dendritic cells
KW - Innate immune response
KW - Interferon γ
KW - Interleukin 2
KW - NK cells
UR - http://www.scopus.com/inward/record.url?scp=3543105567&partnerID=8YFLogxK
U2 - 10.1084/jem.20040370
DO - 10.1084/jem.20040370
M3 - Article
C2 - 15289500
AN - SCOPUS:3543105567
SN - 0022-1007
VL - 200
SP - 287
EP - 295
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 3
ER -