A continuum of T2* components

Flexible fast fraction mapping in sodium MRI

Warda Syeda, Yasmin Blunck, Scott Kolbe, Jon O. Cleary, Leigh A. Johnston

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: Parameter mapping in sodium MRI data is challenging due to inherently low SNR and spatial resolution, prompting the need to employ robust models and estimation techniques. This work aims to develop a continuum model of sodium T 2 -decay to overcome the limitations of the commonly employed bi-exponential models. Estimates of mean T 2 -decay and fast component fraction in tissue are emergent from the inferred continuum model. Methods: A closed-form continuum model was derived assuming a gamma distribution of T 2 components. Sodium MRI was performed on four healthy human subjects and a phantom consisting of closely packed vials filled with an aqueous solution of varying sodium and agarose concentrations. The continuum model was applied to the phantom and in vivo human multi-echo 7T data. Parameter maps by voxelwise model-fitting were obtained. Results: The continuum model demonstrated comparable estimation performance to the bi-exponential model. The parameter maps provided improved contrast between tissue structures. The fast component fraction, an indicator of the heterogeneity of localised sodium motion regimes in tissue, was zero in CSF and high in WM structures. Conclusions: The continuum distribution model provides high quality, high contrast parameter maps, and informative voxelwise estimates of the relative weighting between fast and slow decay components.

Original languageEnglish
Pages (from-to)3854-3864
Number of pages11
JournalMagnetic Resonance in Medicine
Volume81
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019
Externally publishedYes

Keywords

  • continuum model
  • gamma distribution
  • sodium MRI
  • statistical modelling
  • transverse relaxation decay

Cite this

Syeda, Warda ; Blunck, Yasmin ; Kolbe, Scott ; Cleary, Jon O. ; Johnston, Leigh A. / A continuum of T2* components : Flexible fast fraction mapping in sodium MRI. In: Magnetic Resonance in Medicine. 2019 ; Vol. 81, No. 6. pp. 3854-3864.
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abstract = "Purpose: Parameter mapping in sodium MRI data is challenging due to inherently low SNR and spatial resolution, prompting the need to employ robust models and estimation techniques. This work aims to develop a continuum model of sodium T ∗ 2 -decay to overcome the limitations of the commonly employed bi-exponential models. Estimates of mean T ∗ 2 -decay and fast component fraction in tissue are emergent from the inferred continuum model. Methods: A closed-form continuum model was derived assuming a gamma distribution of T ∗ 2 components. Sodium MRI was performed on four healthy human subjects and a phantom consisting of closely packed vials filled with an aqueous solution of varying sodium and agarose concentrations. The continuum model was applied to the phantom and in vivo human multi-echo 7T data. Parameter maps by voxelwise model-fitting were obtained. Results: The continuum model demonstrated comparable estimation performance to the bi-exponential model. The parameter maps provided improved contrast between tissue structures. The fast component fraction, an indicator of the heterogeneity of localised sodium motion regimes in tissue, was zero in CSF and high in WM structures. Conclusions: The continuum distribution model provides high quality, high contrast parameter maps, and informative voxelwise estimates of the relative weighting between fast and slow decay components.",
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A continuum of T2* components : Flexible fast fraction mapping in sodium MRI. / Syeda, Warda; Blunck, Yasmin; Kolbe, Scott; Cleary, Jon O.; Johnston, Leigh A.

In: Magnetic Resonance in Medicine, Vol. 81, No. 6, 01.06.2019, p. 3854-3864.

Research output: Contribution to journalArticleResearchpeer-review

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