A computerised screening instrument for adolescent depression: Population-based validation and application to a two-phase case-control study

G. C. Patton, C. Coffey, M. Posterino, J. B. Carlin, R. Wolfe, G. Bowes

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Computer-administered questionnaires have been little explored as a potentially effective and inexpensive alternative to pencil and paper screening tests. A self-administered computerised form of the revised Clinical Interview Schedule (CIS-R) was compared with the Composite International Diagnostic Interview (CIDI) in a two-phase study of 2032 Australian high school students (mean age 15.7 years) drawn from a stratified random sample of 44 schools in the state of Victoria, Australia. Prevalence, sensitivity and specificity were estimated using weighting to compensate for the two-phase sampling. Point prevalence estimates of depression using the CIS-R were 1.8% for males and 5.6% for females - an overall prevalence of 3.2%. Prevalence estimates for depression in the past 6 months using the CIDI were 5.2% for males and 16.9% for females - an overall estimate of 12.1%. The CIS-R had a positive predictive value (PPV) of 0.49 and negative predictive value (NPV) of 0.91 for CIDI depression in the past 6 months. Specificity was very high (0.97) but sensitivity low (0.18), indicating that a majority of those with a CIDI-defined depressive episode in the past 6 months were not recognised at a single screening using the CIS-R. Even so, the CIS-R has proved at least as good as any pencil and paper questionnaire in identifying cases for nested case-control studies of adolescent depression. Further exploration of strategies such as serial screening to enhance sensitivity is warranted.

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalSocial Psychiatry and Psychiatric Epidemiology
Volume34
Issue number3
DOIs
Publication statusPublished - 1 Jan 1999
Externally publishedYes

Cite this

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title = "A computerised screening instrument for adolescent depression: Population-based validation and application to a two-phase case-control study",
abstract = "Computer-administered questionnaires have been little explored as a potentially effective and inexpensive alternative to pencil and paper screening tests. A self-administered computerised form of the revised Clinical Interview Schedule (CIS-R) was compared with the Composite International Diagnostic Interview (CIDI) in a two-phase study of 2032 Australian high school students (mean age 15.7 years) drawn from a stratified random sample of 44 schools in the state of Victoria, Australia. Prevalence, sensitivity and specificity were estimated using weighting to compensate for the two-phase sampling. Point prevalence estimates of depression using the CIS-R were 1.8{\%} for males and 5.6{\%} for females - an overall prevalence of 3.2{\%}. Prevalence estimates for depression in the past 6 months using the CIDI were 5.2{\%} for males and 16.9{\%} for females - an overall estimate of 12.1{\%}. The CIS-R had a positive predictive value (PPV) of 0.49 and negative predictive value (NPV) of 0.91 for CIDI depression in the past 6 months. Specificity was very high (0.97) but sensitivity low (0.18), indicating that a majority of those with a CIDI-defined depressive episode in the past 6 months were not recognised at a single screening using the CIS-R. Even so, the CIS-R has proved at least as good as any pencil and paper questionnaire in identifying cases for nested case-control studies of adolescent depression. Further exploration of strategies such as serial screening to enhance sensitivity is warranted.",
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A computerised screening instrument for adolescent depression : Population-based validation and application to a two-phase case-control study. / Patton, G. C.; Coffey, C.; Posterino, M.; Carlin, J. B.; Wolfe, R.; Bowes, G.

In: Social Psychiatry and Psychiatric Epidemiology, Vol. 34, No. 3, 01.01.1999, p. 166-172.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - A computerised screening instrument for adolescent depression

T2 - Population-based validation and application to a two-phase case-control study

AU - Patton, G. C.

AU - Coffey, C.

AU - Posterino, M.

AU - Carlin, J. B.

AU - Wolfe, R.

AU - Bowes, G.

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