A comparison of the RIFLE and Acute Kidney Injury Network classifications for cardiac surgery-associated acute kidney injury: a prospective cohort study

Michael Haase, Rinaldo Bellomo, George Matalanis, Paolo Calzavacca, Duska Dragun, Anja Haase-Fielitz

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142 Citations (Scopus)


There is an intense debate on whether the RIFLE (R-renal risk, I-injury, F-failure, L-loss of kidney function, E-end-stage renal disease) classification or its recent modification, the Acute Kidney Injury Network definition and classification system should be used to standardize research on acute kidney injury. In this study we compared these classifications with regard to (1) the detection of acute kidney injury, (2) their agreement according to the grading of acute kidney injury across classes, and (3) their prognostic value. Methods: We prospectively enrolled 282 cardiac surgery patients undergoing cardiopulmonary bypass and assigned a RIFLE and Acute Kidney Injury Network class to each patient. The incidence of acute kidney injury and in-hospital mortality across classes was compared by using the ?2 test, and their prognostic value was compared by using the area under the curve receiver-operating characteristic for in-hospital mortality.
Original languageEnglish
Pages (from-to)1370 - 1376
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number6
Publication statusPublished - 2009
Externally publishedYes

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