Abstract
The RIFLE classification scheme for acute kidney injury (AKI) is based on relative changes in serum creatinine (SCr) and on urine output. The SCr criteria, therefore, require a pre-morbid baseline value. When unknown, current recommendations are to estimate a baseline SCr by the MDRD equation. However, the MDRD approach assumes a glomerular filtration rate of 75 mLmin1.73 m2. This method has not been validated.Methods. Data from the Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) study, a prospective observational study from 54 ICUs in 23 countries of critically ill patients with severe AKI, were analysed. The RIFLE class was determined by using observed (o) pre-morbid and estimated (e) baseline SCr values. Agreement was evaluated by correlation coefficients and Bland-Altman plots. Sensitivity analysis by chronic kidney disease (CKD) status was performed
Original language | English |
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Pages (from-to) | 2739 - 2744 |
Number of pages | 6 |
Journal | Nephrology Dialysis Transplantation |
Volume | 24 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2009 |
Externally published | Yes |