A comparison of haemodynamic responses between head-up tilt and lower body negative pressure

Choon Hian Goh, Branko G. Celler, Nigel H. Lovell, Einly Lim, Wei Yin Lim

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

Abstract

Orthostatic intolerance (OI), a disorder of the autonomic nervous system, it is the development of symptoms when standing upright which are relieved when reclining. Head-up tilt (HUT) table test is a common test for assessing orthostatic tolerance. However, HUT is limited with low sensitivity and specificity. Another approach to stimulate the changing direction and value of the gravity field vector is the lower body negative pressure (LBNP) chamber. The aims of the study is to evaluate the physiological responses of healthy subjects on HUT and LBNP, and examine the relations of two tests. A total of 19 subjects were recruited. A validated wearable device, Sotera Visi Mobile was use to collect physiological signals simultaneously throughout the experiment procedures. Each subject went through a baseline supine rest, 70o of HUT test, another round of baseline supine rest, followed by activation of LBNP test. Three level of suction were applied, i.e. -30 mmHg, -40 mmHg, and -50 mmHg. In this pilot study, healthy subjects showed significantly increased of heart rate, and decreased of systolic blood pressure and diastolic blood pressure, in both HUT and LBNP tests. Although both tests are capable of stimulating a decreased blood volume in the central circulation, but the physiological responses behaved differently and shown only very week correlation. This suggesting that a combination of LBNP test with HUT test might work the best in orthostatic intolerance assessment.

Original languageEnglish
Title of host publication44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages4439-4444
Number of pages6
ISBN (Electronic)9781728127828
DOIs
Publication statusPublished - 2022
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2022 - Glasgow, United Kingdom
Duration: 11 Jul 202215 Jul 2022
Conference number: 44th
https://ieeexplore.ieee.org/xpl/conhome/9870821/proceeding (Proceedings)
https://embc.embs.org/2022/ (Website)

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2022-July
ISSN (Print)1557-170X

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2022
Abbreviated titleEMBC 2022
Country/TerritoryUnited Kingdom
CityGlasgow
Period11/07/2215/07/22
Internet address

Keywords

  • haemodynamic responses
  • head-up tilt
  • lower body negative pressure
  • orthostatic intolerance

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