A comparative study of the effects of repetitive paired transcranial magnetic stimulation on motor cortical excitability

Paul Bernard Fitzgerald, Sarah Fountain, Kate Elizabeth Hoy, Jerome Joseph Maller, Peter Gregory Enticott, Robin Laycock, Daniel Upton, Zafiris J Daskalakis

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17 Citations (Scopus)


Background There is a history of over-prescription of antipsychotics to individuals with intellectual disability (ID), while antidepressants may be under-prescribed. However, appropriate treatment is best supported when the diagnosis of psychosis or depression is valid and carries good predictive validity. The present authors report a study examining one aspect of validity, namely whether skilled clinicians can agree on whether an individual with an ID is psychotic or depressed. Materials and Methods Pairs of clinicians assessed 52 individuals. Agreement was assessed using Cohen s kappa statistic and agreement proportion. Results Overall agreement was high for both psychosis and depression. Whether the individual had mild ID or moderate/severe ID did not have a significant impact on agreement. Conclusions Experienced clinicians achieved a high level of agreement as to whether a person with ID was psychotic or depressed similar to that found for those without ID. The findings provide some support for treatment interventions based on diagnosis.
Original languageEnglish
Pages (from-to)265 - 269
Number of pages5
JournalJournal of Neuroscience Methods
Issue number2
Publication statusPublished - 2007

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