TY - JOUR
T1 - A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: Response to dietary salt load
AU - Dickinson, Hayley
AU - Moritz, Karen Margaret
AU - Wintour-Coghlan, Marelyn
AU - Walker, David William
AU - Kett, Michelle Monica
PY - 2007
Y1 - 2007
N2 - The desert adapted spiny mouse has a significantly lower glomerular number, increased glomerular size, and a more densely packed renal papillae compared to the similarly sized, laboratory adapted C57BL/6 mouse. In the present study we examined the functional consequences of these structural differences in young adult male spiny and C57BL/6 mice and detailed the impact of one week of a high salt (10 NaCl w/w) diet. Basal food and water intake, urine and faeces production, and urinary electrolyte concentrations were not different between species, although urinary urea concentrations were higher in spiny mice (P
AB - The desert adapted spiny mouse has a significantly lower glomerular number, increased glomerular size, and a more densely packed renal papillae compared to the similarly sized, laboratory adapted C57BL/6 mouse. In the present study we examined the functional consequences of these structural differences in young adult male spiny and C57BL/6 mice and detailed the impact of one week of a high salt (10 NaCl w/w) diet. Basal food and water intake, urine and faeces production, and urinary electrolyte concentrations were not different between species, although urinary urea concentrations were higher in spiny mice (P
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17626155
M3 - Article
VL - 293
SP - F1093 - F1098
JO - American Journal of Physiology-Renal Physiology
JF - American Journal of Physiology-Renal Physiology
SN - 1931-857X
IS - 4
ER -