A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: Response to dietary salt load

Hayley Dickinson, Karen Margaret Moritz, Marelyn Wintour-Coghlan, David William Walker, Michelle Monica Kett

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Abstract

The desert adapted spiny mouse has a significantly lower glomerular number, increased glomerular size, and a more densely packed renal papillae compared to the similarly sized, laboratory adapted C57BL/6 mouse. In the present study we examined the functional consequences of these structural differences in young adult male spiny and C57BL/6 mice and detailed the impact of one week of a high salt (10 NaCl w/w) diet. Basal food and water intake, urine and faeces production, and urinary electrolyte concentrations were not different between species, although urinary urea concentrations were higher in spiny mice (P
Original languageEnglish
Pages (from-to)F1093 - F1098
Number of pages6
JournalAmerican Journal of Physiology-Renal Physiology
Volume293
Issue number4
Publication statusPublished - 2007

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