A common somitic origin for embryonic muscle progenitors and satellite cells

Jerome Gros, Marie Manceau, Virginie Thome, Christophe Marcelle

Research output: Contribution to journalLetterOther

Abstract

In the embryo and in the adult, skeletal muscle growth is dependent on the proliferation and the differentiation of muscle progenitors present within muscle masses. Despite the importance of these progenitors, their embryonic origin is unclear. Here we use electroporation of green fluorescent protein in chick somites, video confocal microscopy analysis of cell movements, and quail-chick grafting experiments to show that the dorsal compartment of the somite, the dermomyotome, is the origin of a population of muscle progenitors that contribute to the growth of trunk muscles during embryonic and fetal life. Furthermore, long-term lineage analyses indicate that satellite cells, which are known progenitors of adult skeletal muscles, derive from the same dermomyotome cell population. We conclude that embryonic muscle progenitors and satellite cells share a common origin that can be traced back to the dermomyotome.
Original languageEnglish
Pages (from-to)954 - 958
Number of pages5
JournalNature
Volume435
Issue number7044
Publication statusPublished - 2005

Cite this

Gros, J., Manceau, M., Thome, V., & Marcelle, C. (2005). A common somitic origin for embryonic muscle progenitors and satellite cells. Nature, 435(7044), 954 - 958.
Gros, Jerome ; Manceau, Marie ; Thome, Virginie ; Marcelle, Christophe. / A common somitic origin for embryonic muscle progenitors and satellite cells. In: Nature. 2005 ; Vol. 435, No. 7044. pp. 954 - 958.
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Gros, J, Manceau, M, Thome, V & Marcelle, C 2005, 'A common somitic origin for embryonic muscle progenitors and satellite cells' Nature, vol. 435, no. 7044, pp. 954 - 958.

A common somitic origin for embryonic muscle progenitors and satellite cells. / Gros, Jerome; Manceau, Marie; Thome, Virginie; Marcelle, Christophe.

In: Nature, Vol. 435, No. 7044, 2005, p. 954 - 958.

Research output: Contribution to journalLetterOther

TY - JOUR

T1 - A common somitic origin for embryonic muscle progenitors and satellite cells

AU - Gros, Jerome

AU - Manceau, Marie

AU - Thome, Virginie

AU - Marcelle, Christophe

PY - 2005

Y1 - 2005

N2 - In the embryo and in the adult, skeletal muscle growth is dependent on the proliferation and the differentiation of muscle progenitors present within muscle masses. Despite the importance of these progenitors, their embryonic origin is unclear. Here we use electroporation of green fluorescent protein in chick somites, video confocal microscopy analysis of cell movements, and quail-chick grafting experiments to show that the dorsal compartment of the somite, the dermomyotome, is the origin of a population of muscle progenitors that contribute to the growth of trunk muscles during embryonic and fetal life. Furthermore, long-term lineage analyses indicate that satellite cells, which are known progenitors of adult skeletal muscles, derive from the same dermomyotome cell population. We conclude that embryonic muscle progenitors and satellite cells share a common origin that can be traced back to the dermomyotome.

AB - In the embryo and in the adult, skeletal muscle growth is dependent on the proliferation and the differentiation of muscle progenitors present within muscle masses. Despite the importance of these progenitors, their embryonic origin is unclear. Here we use electroporation of green fluorescent protein in chick somites, video confocal microscopy analysis of cell movements, and quail-chick grafting experiments to show that the dorsal compartment of the somite, the dermomyotome, is the origin of a population of muscle progenitors that contribute to the growth of trunk muscles during embryonic and fetal life. Furthermore, long-term lineage analyses indicate that satellite cells, which are known progenitors of adult skeletal muscles, derive from the same dermomyotome cell population. We conclude that embryonic muscle progenitors and satellite cells share a common origin that can be traced back to the dermomyotome.

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JO - Nature

JF - Nature

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