A combinatorial approach in designing hydrophilic surfaces for solid-phase peptide synthesis

Francesca Ercole; Michael FitzGerald; Senake Perera; Nicholas Ede; Phil Riley; Rhonda Campbell

doi:10.1002/app.12574

A combinatorial approach in designing hydrophilic surfaces for solid-phase peptide synthesis

Francesca Ercole, Michael FitzGerald, Senake Perera, Nicholas Ede, Phil Riley, Rhonda Campbell

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

A hydrophilic surface suitable for solid-state peptide synthesis was developed on a solid support called a lantern. The split-and-mix combinatorial technique was used to prepare about 500 surfaces in a very short time. Surfaces were analyzed according to values for gel formation, percentage weight grafted, grafted copolymer composition, and number of functional groups per lantern. These values were correlated to the purity of a peptide synthesized on these surfaces.

Original language	English
Pages (from-to)	3371-3378
Number of pages	8
Journal	Journal of Applied Polymer Science
Volume	89
Issue number	12
DOIs	https://doi.org/10.1002/app.12574
Publication status	Published - 1 Jul 2003
Externally published	Yes

Keywords

Peptides
Supports
Surfaces
Synthesis

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10.1002/app.12574

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AU - Perera, Senake

AU - Ede, Nicholas

AU - Riley, Phil

AU - Campbell, Rhonda

PY - 2003/7/1

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AB - A hydrophilic surface suitable for solid-state peptide synthesis was developed on a solid support called a lantern. The split-and-mix combinatorial technique was used to prepare about 500 surfaces in a very short time. Surfaces were analyzed according to values for gel formation, percentage weight grafted, grafted copolymer composition, and number of functional groups per lantern. These values were correlated to the purity of a peptide synthesized on these surfaces.

KW - Peptides

KW - Supports

KW - Surfaces

KW - Synthesis

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ER -

A combinatorial approach in designing hydrophilic surfaces for solid-phase peptide synthesis

Abstract

Keywords

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