A combinatorial approach in designing hydrophilic surfaces for solid-phase peptide synthesis

Francesca Ercole, Michael FitzGerald, Senake Perera, Nicholas Ede, Phil Riley, Rhonda Campbell

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A hydrophilic surface suitable for solid-state peptide synthesis was developed on a solid support called a lantern. The split-and-mix combinatorial technique was used to prepare about 500 surfaces in a very short time. Surfaces were analyzed according to values for gel formation, percentage weight grafted, grafted copolymer composition, and number of functional groups per lantern. These values were correlated to the purity of a peptide synthesized on these surfaces.

Original languageEnglish
Pages (from-to)3371-3378
Number of pages8
JournalJournal of Applied Polymer Science
Volume89
Issue number12
DOIs
Publication statusPublished - 1 Jul 2003
Externally publishedYes

Keywords

  • Peptides
  • Supports
  • Surfaces
  • Synthesis

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