A closer look at visually guided saccades in autism and Asperger's disorder

Beth Patricia Johnson, Nicole Joan Rinehart, Nicole Papadopoulos, Bruce John Tonge, Lynette Millist, Owen B White, Joanne Fielding

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Motor impairments have been found to be a significant clinical feature associated with autism and Asperger s disorder (AD) in addition to core symptoms of communication and social cognition deficits. Motor deficits in high-functioning autism (HFA) and AD may differentiate these disorders, particularly with respect to the role of the cerebellum in motor functioning. Current neuroimaging and behavioural evidence suggests greater disruption of the cerebellum in HFA than AD. Investigations of ocular motor functioning have previously been used in clinical populations to assess the integrity of the cerebellar networks, through examination of saccade accuracy and the integrity of saccade dynamics. Previous investigations of visually guided saccades in HFA and AD have only assessed basic saccade metrics, such as latency, amplitude and gain, as well as peak velocity. We used a simple visually guided saccade paradigm to further characterize the profile of visually guided saccade metrics and dynamics in HFA and AD. It was found that children with HFA, but not AD, were more inaccurate across both small (5A?) and large (10A?) target amplitudes, and final eye position was hypometric at 10A?. These findings suggest greater functional disturbance of the cerebellum in HFA than AD, and suggest fundamental difficulties with visual error monitoring in HFA
Original languageEnglish
Article number99
Pages (from-to)1 - 7
Number of pages7
JournalFrontiers in Integrative Neuroscience
Volume6
DOIs
Publication statusPublished - 2012

Cite this

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title = "A closer look at visually guided saccades in autism and Asperger's disorder",
abstract = "Motor impairments have been found to be a significant clinical feature associated with autism and Asperger s disorder (AD) in addition to core symptoms of communication and social cognition deficits. Motor deficits in high-functioning autism (HFA) and AD may differentiate these disorders, particularly with respect to the role of the cerebellum in motor functioning. Current neuroimaging and behavioural evidence suggests greater disruption of the cerebellum in HFA than AD. Investigations of ocular motor functioning have previously been used in clinical populations to assess the integrity of the cerebellar networks, through examination of saccade accuracy and the integrity of saccade dynamics. Previous investigations of visually guided saccades in HFA and AD have only assessed basic saccade metrics, such as latency, amplitude and gain, as well as peak velocity. We used a simple visually guided saccade paradigm to further characterize the profile of visually guided saccade metrics and dynamics in HFA and AD. It was found that children with HFA, but not AD, were more inaccurate across both small (5A?) and large (10A?) target amplitudes, and final eye position was hypometric at 10A?. These findings suggest greater functional disturbance of the cerebellum in HFA than AD, and suggest fundamental difficulties with visual error monitoring in HFA",
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A closer look at visually guided saccades in autism and Asperger's disorder. / Johnson, Beth Patricia; Rinehart, Nicole Joan; Papadopoulos, Nicole; Tonge, Bruce John; Millist, Lynette; White, Owen B; Fielding, Joanne.

In: Frontiers in Integrative Neuroscience, Vol. 6, 99, 2012, p. 1 - 7.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Motor impairments have been found to be a significant clinical feature associated with autism and Asperger s disorder (AD) in addition to core symptoms of communication and social cognition deficits. Motor deficits in high-functioning autism (HFA) and AD may differentiate these disorders, particularly with respect to the role of the cerebellum in motor functioning. Current neuroimaging and behavioural evidence suggests greater disruption of the cerebellum in HFA than AD. Investigations of ocular motor functioning have previously been used in clinical populations to assess the integrity of the cerebellar networks, through examination of saccade accuracy and the integrity of saccade dynamics. Previous investigations of visually guided saccades in HFA and AD have only assessed basic saccade metrics, such as latency, amplitude and gain, as well as peak velocity. We used a simple visually guided saccade paradigm to further characterize the profile of visually guided saccade metrics and dynamics in HFA and AD. It was found that children with HFA, but not AD, were more inaccurate across both small (5A?) and large (10A?) target amplitudes, and final eye position was hypometric at 10A?. These findings suggest greater functional disturbance of the cerebellum in HFA than AD, and suggest fundamental difficulties with visual error monitoring in HFA

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